The 1946 Massachusetts general election was held on November 5, 1946, throughout Massachusetts. Primary elections took place on June 18.

At the federal level, Republican Henry Cabot Lodge Jr. was elected to the United States Senate over incumbent Senator David I. Walsh, and Republicans won nine of fourteen seats in the United States House of Representatives. Future President of the United States John F. Kennedy was elected to his first term in the House.

In the race for Governor, Republican Lt. Governor Robert F. Bradford defeated incumbent Democrat Maurice Tobin. Overall, Republicans won five of the six elected state-wide offices. Only incumbent Democratic Auditor Thomas J. Buckley retained his office.

Republican Lieutenant Governor Robert F. Bradford defeated incumbent Democratic Governor Maurice Tobin. Tobin survived a Democratic primary challenge from attorney Francis Harrigan, while Bradford was unopposed for the Republican nomination.

In the race for lieutenant governor, Republican State Senator Arthur W. Coolidge defeated Democratic former attorney general Paul A. Dever.

State Senator Arthur W. Coolidge defeated Lynn mayor Albert Cole in the Republican primary for Lieutenant Governor.

Former Attorney General Paul A. Dever defeated Roger Putnam, Daniel J. O'Connell, and John B. Carr for the Democratic nomination for Lt. Governor.

Incumbent Republican Secretary of the Commonwealth Frederic W. Cook ran for re-election to a thirteenth two-year term in office.