The 2016 season was the Seattle Seahawks' 41st in the National Football League (NFL) and their seventh under head coach Pete Carroll. On October 23, the team played the Arizona Cardinals in a game that ended in a 6–6 tie, the Seahawks' first tie in franchise history. With their win against the Los Angeles Rams in Week 15, the Seahawks claimed their third NFC West title in the last four years. The Seahawks defeated the Detroit Lions in the Wild Card Round but lost 36–20 to the eventual NFC champion Atlanta Falcons in the Divisional Round.

For the first time since trading for him in 2010, Marshawn Lynch did not play for the Seahawks as he retired in the offseason. Lynch would later come out of retirement to play for his hometown team Oakland Raiders before their relocation to Las Vegas. He ultimately rejoined the Seahawks in December 2019.

Draft trades

All undrafted free agents were signed after the 2016 NFL draft concluded on April 30, unless noted otherwise.

The Seahawks' preliminary preseason schedule was announced on April 7. Exact dates and times were finalized on April 14, when the regular season schedule was announced.

Divisional matchups: the NFC West played the NFC South and the AFC East.

Note: Intra-division opponents are in bold text.

at CenturyLink Field, Seattle, Washington