The A5 motorway (Croatian: Autocesta A5) is a motorway in Croatia spanning 88.6 kilometres (55.1 mi). It connects Osijek, the largest city in Slavonia region, to the Croatian motorway network at the Sredanci interchange of the A3 motorway. The A5 represents a significant north–south transportation corridor in Croatia and is a part of the European route E73. The A5 motorway route also follows Pan-European corridor Vc. In addition to Osijek, the A5 motorway also passes near Đakovo and Beli Manastir.

The first section of the A5, joining the Sredanci interchange to Đakovo, was opened in 2007; the route to Osijek opened in 2009. In 2015, the first section south of the A3, from Sredanci interchange to Svilaj was opened, and the second one, extending to the Sava River and border of Bosnia and Herzegovina, along with the Svilaj bridge on the Croatia – Bosnia and Herzegovina border was opened in 2021. The section between Osijek and Beli Manastir was opened in 2022. The section between Beli Manastir and Hungary was opened in 2025.

Once the entire Pan-European corridor Vc is completed, motorists will recognize the A5's importance as a transit route. When completed, the corridor shall entail the A5 itself extended to the Hungarian border and connected to the Hungarian M6 motorway as well as Bosnia and Herzegovina's A1 motorway and the A10 motorway, completing the corridor route at the Adriatic Sea coast.

The motorway consists of two traffic lanes and an emergency lane in each driving direction separated by a central reservation. All intersections of the A5 motorway are grade separated. There are five exits and four rest areas operating along the route. The motorway is tolled using a ticket system, integrated with the A3, and each exit includes a toll plaza.

The A5 is an important north–south motorway covering 59 kilometres (37 mi) in the eastern Croatian region of Slavonia, connecting the region's largest city, Osijek, to the remainder of the Croatian motorway system. The A5's southern terminus joins the A3 motorway at the Sredanci interchange; its northern terminus is near Osijek, connecting to the city's southern bypass. As a part of the road network of Croatia, the A5 is a part of European route E73. The motorway is of great importance to Croatia's economic development, especially tourism, as it represents a major southward transport route from southern Hungary. The Pan-European corridor Vc will include the A5, and its completion will highlight the importance of the A5 motorway.

The cities and towns with an immediate connection to the A5 include Beli Manastir via the D517, Đakovo via the D7 and Čepin via the Ž4105 county road. The A5 motorway consists of two traffic lanes and an emergency lane in each driving direction, with carriageways separated by the median. All existing interchanges are trumpet interchanges, except for Sredanci, which is a cloverleaf. The A5 features a number of rest areas which provide various services including restrooms, filling stations and restaurants. The motorway has four interchanges, providing access to several towns and cities and the Croatian state road network. The motorway is maintained and operated by the state-owned management company Hrvatske autoceste.

An automatic traffic monitoring and guidance system is in place along the motorway. It consists of measuring, control and signaling devices, located in zones where driving conditions may vary—at interchanges, near viaducts and bridges, and areas where fog is common. The system uses variable traffic signs to communicate driving conditions, possible restrictions and other information to motorists.

The A5 motorway runs through plains crossed by a number of watercourses and railways running perpendicular to the motorway route, requiring a variety of bridges and viaducts. Particular attention to the environment is also necessary, due to water supply and natural heritage zones, as well as nearby agricultural production.