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Lymphopoiesis

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Lymphopoiesis

Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cells (WBCs).[page needed] It is more formally known as lymphoid hematopoiesis.

Disruption in lymphopoiesis can lead to a number of lymphoproliferative disorders, such as lymphomas and lymphoid leukemias.

Lymphocytes are blood cells of lymphoid (rather than the myeloid or erythroid) lineage.

Lymphocytes are found in the bloodstream and originate in the bone marrow, however, they principally belong to the separate lymphatic system, which interacts with the blood circulation.[citation needed]

Lymphopoiesis is now usually used interchangeably with the term "lymphocytopoiesis" – the making of lymphocytes, but some sources distinguish between the two, stating that "lymphopoiesis" additionally refers to creating lymphatic tissue, while "lymphocytopoiesis" refers only to the creation of cells in that tissue. It is rare now for lymphopoiesis to refer to the creation of lymphatic tissues.[citation needed]

Myelopoiesis refers to the "generation of cells of the myeloid lineage" and erythropoiesis refers to the "generation of cells of the erythroid lineage", so parallel usage has evolved in which lymphopoiesis refers to the "generation of cells of the lymphoid lineage".[citation needed]

The two classes of WBCs in mice originate from cells with strong stem cell properties – myeloids from the common myeloid progenitor (CMP), and lymphoids from the common lymphoid progenitor (CLP).[page needed] It was eventually found these progenitors were not unique, and that the myeloid and lymphoid classes were not disjoint, but rather two partially interwoven family trees.[citation needed]

Mature lymphocytes are a critical part of the immune system that, with the exception of memory B and T cells, have short lives measured in days or weeks and must be continuously generated throughout life by cell division and differentiation from cells such as common lymphoid progenitors (CLPs) in mice.[citation needed]

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