Mesolambdolophus is an extinct genus of small odd-toed ungulate known from the Bridgerian North American Stage (late Early to early Middle Eocene) of Wyoming, United States. It is known only from the holotype MCZ 19585, a nearly complete mandible which was collected from the Bridger Formation. It was first named by Luke T. Holbrook and Joshua Lapergola in 2011 and the type species is Mesolambdolophus setoni.