Pinopolis is an unincorporated community and census-designated place in Berkeley County, South Carolina, United States. As of the 2010 census it had a population of 948.

Founded circa 1845, the community was established at a relatively high elevation in the "low country" of South Carolina, and it gave an escape from mosquitoes and uncomfortable heat. It became a gathering place for those of means during this time. It shared this aspect with other communities throughout the plantation economy of this era.^{[citation needed]}

A resident spontaneously coined the name "Pinopolis" because of the many pine trees. This is probably a reflection of schooling that included references to Greek and Latin.

During the pre-Civil War period it developed in this way and maintained as a place of polish and refinement. In the post-Civil War period and during the change of the South, it became the location of the first elementary school for black students.^{[citation needed]}

In 1939, the Santee Cooper Project dammed the Santee River, flooding nearly 175,000 acres (710 km²) and creating Lake Moultrie with the Pinopolis Dam in 1946. Because of its high elevation, Pinopolis was spared from the flooding, and now exists as a peninsula on the lake.^{[citation needed]}

The Pinopolis Historic District North, Pinopolis Historic District South, and William Robertson House are listed on the National Register of Historic Places.