The Pleistocene (/ˈplaɪstəˌsiːn, -stoʊ-/ PLY-stə-seen, -⁠stoh-; referred to colloquially as the Ice Age) is the geological epoch that lasted from c. 2.58 million to 11,700 years ago, spanning the Earth's most recent period of repeated glaciations. Before a change was finally confirmed in 2009 by the International Union of Geological Sciences, the cutoff of the Pleistocene and the preceding Pliocene was regarded as being 1.806 million years Before Present (BP). Publications from earlier years may use either definition of the period. The end of the Pleistocene corresponds with the end of the last glacial period and also with the end of the Paleolithic age used in archaeology. The name comes from Ancient Greek πλεῖστος (pleîstos), meaning "most", and καινός (kainós), meaning "new, recent".

The aridification and cooling trends of the preceding Neogene were continued in the Pleistocene. The climate was strongly variable depending on the glacial cycle, oscillating between cold glacial periods and warmer interglacials, with the sea levels being up to 120 metres (390 ft) lower than present at peak glaciation, allowing the periodic connection of Asia and North America via the Beringia land bridge, and the covering of most of northern North America by the large Laurentide Ice Sheet.

At the end of the preceding Pliocene, the previously isolated North and South American continents were joined by the Isthmus of Panama, causing a faunal interchange between the two regions and changing ocean circulation patterns, with the onset of glaciation in the Northern Hemisphere occurring around 2.7 million years ago. During the Early Pleistocene (2.58–0.8 Ma), archaic humans of the genus Homo originated in Africa and spread throughout Afro-Eurasia. The end of the Early Pleistocene is marked by the Mid-Pleistocene Transition, with the cyclicity of glacial cycles changing from 41,000-year cycles to asymmetric 100,000-year cycles, making the climate variation more extreme. The Late Pleistocene witnessed the spread of modern humans outside Africa as well as the extinction of all other human species. Humans also spread to the Australian continent and the Americas for the first time.

The Late Pleistocene from around 50,000 years ago onwards was marked by the extinction of most large terrestrial animals outside of Africa, an extinction event otherwise unprecedented in the geological record due to its extreme size bias. Most authors suggest that climate change, the expansion of modern humans, or the combination of both were the likely causes of the extinctions.

Charles Lyell introduced the term "Pleistocene" in 1839 to describe strata in Sicily that had at least 70% of their molluscan fauna still living today. This distinguished it from the older Pliocene Epoch, which Lyell had originally thought to be the youngest fossil rock layer. He constructed the name "Pleistocene" ('most new' or 'newest') from the Greek πλεῖστος (pleīstos) 'most' and καινός (kainós (Latinized as cænus) 'new'). This contrasts with the immediately preceding Pliocene ("newer", from πλείων (pleíōn, "more") and kainós) and the immediately subsequent Holocene ("wholly new" or "entirely new", from ὅλος (hólos, "whole") and kainós) epoch, which extends to the present time.

The Pleistocene has been dated from 2.580 million (±0.005) to 11,700 years BP with the end date expressed in radiocarbon years as 10,000 carbon-14 years BP. It covers most of the latest period of repeated glaciation, up to and including the Younger Dryas cold spell. The end of the Younger Dryas has been dated to about 9700 BCE (11,700 years before present). The end of the Younger Dryas is the official start of the current Holocene Epoch. Although it is considered an epoch, the Holocene was not significantly different in terms of temperature change than previous Pleistocene interglacial intervals, although the rapid onset of the Anthropocene is unprecedented. In the ICS timescale, the Pleistocene is divided into four stages or ages, the Gelasian, Calabrian, Chibanian (previously the unofficial "Middle Pleistocene"), and Upper Pleistocene (unofficially the "Tarantian"). In addition to these international subdivisions, various regional subdivisions are often used.

In 2009 the International Union of Geological Sciences (IUGS) confirmed a change in time period for the Pleistocene, changing the start date from 1.806 to 2.588 million years BP, and accepted the base of the Gelasian as the base of the Pleistocene, namely the base of the Monte San Nicola GSSP. The start date has now been rounded down to 2.580 million years BP. The IUGS has yet to approve a type section, Global Boundary Stratotype Section and Point (GSSP), for the upper Pleistocene/Holocene boundary (i.e. the upper boundary). The proposed section is the North Greenland Ice Core Project ice core 75° 06' N 42° 18' W. The lower boundary of the Pleistocene Series is formally defined magnetostratigraphically as the base of the Matuyama (C2r) chronozone, isotopic stage 103. Above this point there are notable extinctions of the calcareous nannofossils: Discoaster pentaradiatus and Discoaster surculus. The Pleistocene covers the recent period of repeated glaciations.

The name Plio-Pleistocene has, in the past, been used to mean the last ice age. Formerly, the boundary between the two epochs was drawn at the time when the foraminiferal species Hyalinea baltica first appeared in the marine section at La Castella, Calabria, Italy. However, the revised definition of the Quaternary, by pushing back the start date of the Pleistocene to 2.58 Ma, results in the inclusion of all the recent repeated glaciations within the Pleistocene.