The fifth and final season of Prison Break (also known as Prison Break: Resurrection) is a limited event television series and a revival of the original series created by Paul Scheuring that aired on Fox from 2005 to 2009. The season is produced by 20th Century Fox Television in association with Adelstein Productions, Dawn Olmstead Productions, One Light Road Productions and Original Film. Paul Scheuring serves as showrunner, with himself, Marty Adelstein, Neal H. Moritz and Dawn Olmstead, Vaun Wilmott, Michael Horowitz and Nelson McCormick serving as executive producers. McCormick also serves as director. The season premiered on April 4, 2017, and concluded on May 30, 2017, consisting of 9 episodes.

Wentworth Miller and Dominic Purcell reprise their respective roles as Michael Scofield and Lincoln Burrows, while Sarah Wayne Callies, Amaury Nolasco, Paul Adelstein, Robert Knepper and Rockmond Dunbar also return from the original series. New cast additions include Mark Feuerstein, Inbar Lavi, Augustus Prew, Marina Benedict, Rick Yune and Steve Mouzakis. A pilot was ordered in August 2015 and the series was greenlit in January 2016. Production on the series began in April 2016 and filming took place in Vancouver and the Moroccan cities of Rabat, Casablanca, and Ouarzazate.

Seven years after his apparent death, Michael Scofield resurfaces in the notorious Ogygia Prison in Sanaa, Yemen, under the name Kaniel Outis. As the country is engulfed by war, two of Michael's oldest friends, his brother Lincoln Burrows and fellow Fox River escapee C-Note, risk their lives by traveling to Yemen to bring Michael home. Back in the United States, Michael's wife Sara, now remarried, is hunted by agents of an operative known as Poseidon, the one responsible for Michael's disappearance.

On January 12, 2015, at the 2015 Winter TCA Press Tour, Wentworth Miller and Dominic Purcell revealed the possibility that Fox was interested in bringing back Prison Break, with Miller stating: "We actually floated the idea to Fox very casually and they seemed very not casual about this interest. They seemed to think there was something there." Purcell concluded by adding, "It's something that Fox is, as Wentworth said, potentially excited about."

On January 17, 2015, Fox Television Group chairman and CEO Gary Newman made it clear that they would love to bring Prison Break back for another run, although Fox had nothing to report. Newman himself stated, "There's some speculation in the press at Prison Break and we've made it clear at the studio that we'd bring Prison Break back at the studio [...] It's the perfect event series. But at the moment, we have nothing else to report."

On June 2, 2015, it was reported that a limited series revival of Paul Scheuring's Prison Break was in development at Fox.

On August 6, 2015, Fox confirmed a 10-episode order for the revival. The limited series is a sequel to the original series, taking place several years later, and features Miller and Purcell reprising their roles as well as the return of other original characters. Fox Television Group chairman and CEO Dana Walden herself stated that Prison Break has performed particularly well internationally and on SVOD platforms such as Netflix. Walden added that: "a logical and believable explanation to why the characters are alive and still moving around the world [...]" Walden said. "The brothers and some of the iconic characters will be back, and it will address some questions that were set up at the end of the series for a new audience."

On January 15, 2016, Fox officially ordered the revival to series, with the episode order revised to nine episodes, though Fox declined to announce how many episodes the series will run. The original producing team of creator Paul Scheuring, Neal Moritz, Marty Adelstein and Dawn Olmstead were all confirmed as to return for the event series as executive producers and Scheuring writing and serving as showrunner and Miller and Purcell being producers of the season. Luca Tranchino served as production designer.