South Florida, sometimes colloquially shortened to SoFlo, is the southernmost region of the U.S. state of Florida. It is one of Florida's three most commonly referred to directional regions; the two others are Central Florida and North Florida. South Florida is the southernmost part of the continental United States and the only region of the continental U.S. that includes some areas with a tropical climate.

South Florida is dominated by the Miami metropolitan area and the Everglades. It also contains the Florida Keys; three U.S. national parks: Biscayne, Dry Tortugas, and Everglades; and multiple cities.

As with all vernacular regions, South Florida has no official boundaries or status and is defined differently by different sources. A 2007 study of Florida's regions by Ary Lamme and Raymond K. Oldakowski found that Floridians surveyed identified "South Florida" as comprising the southernmost sections of peninsular Florida, meaning from Jupiter, Florida south. That area includes the Miami metropolitan area, defined as Miami-Dade, Broward, and Palm Beach counties, the Florida Keys, and the interior region known as the Glades.

The term South Florida most commonly refers to the Miami metro’s tri-county area, interpretations vary on the inclusion of some other parts of Florida within the South Florida region, such as the inclusion of Southwest Florida and the Treasure Coast. Southwest Florida, representing the state's Gulf Coast, has emerged as a directional vernacular region. Respondents from as far northwest as the Tampa Bay area identified their region as being in Central Florida. Confusing the matter further, the University of South Florida, named in part because of its status as the state's southernmost public university at the time of its 1957 founding, is located in Tampa. Florida State Road 70 bisects approximately in the Central Florida region from west to east. However, Tampa is not considered South Florida region.

Enterprise Florida, the state's economic development agency, identifies "Southeast Florida" as one of eight economic regions used by the agency and other state and outside entities, including the Florida Department of Transportation. Some entities alternately designate this region "South Florida". Its definition includes much of the same territory as Lamme and Oldakowski's report, except the Gulf Coast and much of the interior Glades region. It includes Monroe County and the three metropolitan counties of Miami-Dade, Broward, and Palm Beach, as well as the three "Treasure Coast" counties of Indian River, St. Lucie, and Martin to the north.

The demographics of South Florida residents can be segmented as following:

Over 87.2% of all foreigners residing in South Florida come from Latin America.

South Florida is politically diverse, with multiple congressional districts in the region supporting both the Democratic and Republican parties. As evidenced by the 2020 United States presidential election, supporters of the Democratic Party are mostly concentrated in urban areas, as well as areas to the west of and including downtown Key West, rural communities surrounding Immokalee, and the areas surrounding Belle Glade, while supporters of the Republican Party reside in the most costal regions of the Miami area north of Pompano Beach, most of the Everglades, most of the regions between Port St. Lucie and Riviera Beach, Southwest Florida, and a supermajority of the region's inland and rural areas.