FLOT1

FLOT1
Identifiers
Aliases	FLOT1, flotillin 1
External IDs	OMIM: 606998; MGI: 1100500; HomoloGene: 31337; GeneCards: FLOT1; OMA:FLOT1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,742,732 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	36,143,683 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; left adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; apex of heart; ; blood; ; C1 segment; ; dorsolateral prefrontal cortex; ; left ventricle; ; cerebellum;
	Top expressed in
	granulocyte; ; interventricular septum; ; cardiac muscle tissue of left ventricle; ; right ventricle; ; dentate gyrus of hippocampal formation granule cell; ; ankle joint; ; sciatic nerve; ; facial motor nucleus; ; spinal ganglia; ; visual cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protease binding; protein binding; protein heterodimerization activity; ionotropic glutamate receptor binding;
Cellular component	integral component of membrane; endosome; membrane; cell-cell contact zone; focal adhesion; plasma membrane raft; melanosome; plasma membrane; centriolar satellite; microtubule organizing center; lysosomal membrane; flotillin complex; uropod; basolateral plasma membrane; early endosome; apical plasma membrane; cortical actin cytoskeleton; caveola; membrane raft; COP9 signalosome; sarcolemma; extracellular exosome; cytoplasmic vesicle; lamellipodium; cell-cell junction; external side of plasma membrane; synapse; presynaptic active zone; dopaminergic synapse; presynapse; glutamatergic synapse; GABA-ergic synapse;
Biological process	positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of cell adhesion molecule production; positive regulation of protein phosphorylation; regulation of toll-like receptor 4 signaling pathway; positive regulation of heterotypic cell-cell adhesion; positive regulation of toll-like receptor 3 signaling pathway; axonogenesis; positive regulation of skeletal muscle tissue development; positive regulation of cytokine production; extracellular matrix disassembly; protein kinase C signaling; response to endoplasmic reticulum stress; positive regulation of myoblast fusion; positive regulation of endocytosis; positive regulation of cell junction assembly; protein localization to membrane raft; membrane raft assembly; cellular response to exogenous dsRNA; regulation of receptor internalization; positive regulation of synaptic transmission, dopaminergic; positive regulation of protein binding; regulation of Rho protein signal transduction; protein homooligomerization; dsRNA transport; plasma membrane raft assembly; positive regulation of interferon-beta production; protein stabilization; protein localization to plasma membrane; regulation of neurotransmitter uptake; positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	10211
	14251
ENSG00000137312; ENSG00000232280; ENSG00000224740; ENSG00000206480; ENSG00000206379;
	ENSG00000230143; ENSG00000236271; ENSG00000223654
	ENSMUSG00000059714
	O75955
	O08917
	NM_005803; NM_001318875
	NM_008027
	NP_001305804; NP_005794
	NP_032053
	Wikidata
View/Edit Human	View/Edit Mouse

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.^[5]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein.^[6] The function of flotillin 1 has not been determined.^[5]

Interactions

FLOT1 has been shown to interact with SORBS1.^[7]^[8]^[9]

References

^ ^a ^b ^c ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 GRCh38: Ensembl release 89: ENSG00000137312, ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059714 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: FLOT1 flotillin 1".
^ Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF (May 1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins". J. Biol. Chem. 272 (21): 13793–802. doi:10.1074/jbc.272.21.13793. PMID 9153235.
^ Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873. S2CID 14083271.
^ Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (September 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. doi:10.1038/35025089. hdl:2027.42/62940. PMID 11001060. S2CID 4334519.
^ Kimura A, Baumann CA, Chiang SH, Saltiel AR (July 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476.

External links

FLOT1 human gene location in the UCSC Genome Browser.
FLOT1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 GRCh38: Ensembl release 89: ENSG00000137312, ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059714 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FLOT1 flotillin 1".

[pmid9153235-6] Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF (May 1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins". J. Biol. Chem. 272 (21): 13793–802. doi:10.1074/jbc.272.21.13793. PMID 9153235.

[pmid15128873-7] Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873. S2CID 14083271.

[pmid11001060-8] Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (September 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. doi:10.1038/35025089. hdl:2027.42/62940. PMID 11001060. S2CID 4334519.

[pmid11481476-9] Kimura A, Baumann CA, Chiang SH, Saltiel AR (July 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476.

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