The 2006–07 Maltese First Division Knock-Out (known as EuroSport First Division Knock-Out due to sponsorship reasons) was a knockout tournament for Maltese football clubs playing in the First Division. The winners were Tarxien Rainbows and the runner-up were Mosta.
The competition began on 18 November 2006 and ended on 24 May 2007 with the final.
The competition began with the preliminary round. Four teams played in the preliminary round. The two winners from the preliminary round advanced to the quarter-finals with the rest of the teams of the First Division. The four winners of the quarter-finals, which were Mosta, Senglea Athletic, St. Patrick and Tarxien Rainbows advanced to the semi-finals.
| Team 1 | Score | Team 2 |
|---|---|---|
| 18 November 2006 | ||
| Ħamrun Spartans | 0–1 (a.e.t.) | Senglea Athletic |
| Mqabba | 3–0 | Naxxar Lions |
| Team 1 | Score | Team 2 |
|---|---|---|
| 7 April 2007 | ||
| Vittoriosa Stars | 1–3 | Senglea Athletic |
| St. Patrick | 3–1 | Qormi |
| 8 April 2007 | ||
| Mosta | 3–1 | San Gwann |
| Tarxien Rainbows | 2–1 | Mqabba |
| Team 1 | Score | Team 2 |
|---|---|---|
| 19 May 2007 | ||
| Senglea Athletic | 1–4 | Mosta |
| Tarxien Rainbows | 1–1 (a.e.t.) (5–4 p) | St. Patrick |
| Team 1 | Score | Team 2 |
|---|---|---|
| 24 May 2007 | ||
| Mosta | 1–2 | Tarxien Rainbows |
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