The 2018 Bojangles' Southern 500, the 69th running of the event was a Monster Energy NASCAR Cup Series race held on September 2, 2018, at Darlington Raceway in Darlington, South Carolina. Contested over 367 laps on the 1.366-mile (2.198 km) egg-shaped oval, it was the 25th race of the 2018 Monster Energy NASCAR Cup Series season. This race marked the final career start for Kasey Kahne.

Darlington Raceway is a race track built for NASCAR racing located near Darlington, South Carolina. It is nicknamed "The Lady in Black" and "The Track Too Tough to Tame" by many NASCAR fans and drivers and advertised as "A NASCAR Tradition." It is of a unique, somewhat egg-shaped design, an oval with the ends of very different configurations, a condition which supposedly arose from the proximity of one end of the track to a minnow pond the owner refused to relocate. This situation makes it very challenging for the crews to set up their cars' handling in a way that is effective at both ends.

Denny Hamlin was the fastest in the first practice session with a time of 28.543 seconds and a speed of 172.287 mph (277.269 km/h).

Ryan Newman was the fastest in the final practice session with a time of 28.641 seconds and a speed of 171.698 mph (276.321 km/h).

Denny Hamlin scored the pole for the race with a time of 28.332 and a speed of 173.571 mph (279.335 km/h).

Stage 1 Laps: 100

Stage 2 Laps: 100

Stage 3 Laps: 167