| 2018 Columbus Challenger | |
|---|---|
| Date | 17–23 September |
| Edition | 5th |
| Draw | 32S / 16D |
| Surface | Hard / Indoors |
| Location | Columbus, United States |
| Champions | |
| Singles | |
 Michael Mmoh | |
| Doubles | |
Tommy Paul /  Peter Polansky | |
The 2018 Columbus Challenger was a professional tennis tournament played on indoor hard courts. It was the fifth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Columbus, United States between 17 and 23 September 2018.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 AUS
|
Jordan Thompson | 111 | 1 |
| CAN
|
Peter Polansky | 112 | 2 |
| USA
|
Michael Mmoh | 122 | 3 |
| USA
|
Reilly Opelka | 143 | 4 |
 GER
|
Dominik Köpfer | 188 | 5 |
| AUS
|
Alexei Popyrin | 194 | 6 |
 ECU
|
Roberto Quiroz | 213 | 7 |
| AUS
|
Maverick Banes | 220 | 8 |
The following players received entry into the singles main draw as wildcards:
Martin Joyce John McNally
Mikael Torpegaard J. J. WolfThe following player received entry into the singles main draw as a special exempt:
The following players received entry from the qualifying draw:
Thai-Son Kwiatkowski Luke Saville Ryan Shane Evan SongThe following player received entry as a lucky loser:
Michael Mmoh def. Jordan Thompson 6–3, 7–6(7–4). Tommy Paul / Peter Polansky def. Gonzalo Escobar / Roberto Quiroz 6–3, 6–3.
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