The 2021 USL Championship playoffs (branded as the 2021 USL Championship Playoffs presented by TwinSpires for sponsorship reasons) was the post-season championship of the 2021 USL Championship. It was the eleventh edition of the USL Championship playoffs. The playoffs began on November 5, and concluded with the USL Championship Final on November 28.

Tampa Bay Rowdies won the regular season with 71 standings points. They were beaten in the Final by Orange County SC, which won its first league title.

Real Monarchs, having won the title in 2019, were the title holders, since the 2020 Final was cancelled due to the COVID-19 outbreak in the Rowdies and the title was not awarded. However, they were eliminated in the regular season as they finished bottom of the Mountain Division table.

The top four teams in each division qualified for the playoffs. They began to play on the first weekend on November, featuring a single-elimination, 16-team bracket. Under the revised season format, four division winners in each conference earned hosting rights for the Eastern and Western conference quarterfinals. Following the opening round, hosting rights were determined by regular season record (ranks, then points, then number of wins). All playoff matches were streamed live on ESPN+ except the Championship final on ESPN, ESPN Deportes, and SiriusXM FC.

Championship Game MVP: Ronaldo Damus (Orange County SC)