The 48th Annual Grammy Awards took place on February 8, 2006, at the Staples Center in Los Angeles, California honoring the best in music for the recording year beginning from October 1, 2004, through September 30, 2005. Irish rock band U2 were the main recipients with five awards including Album of the Year. Mariah Carey, John Legend, and Kanye West were each nominated for eight awards and won three; Alison Krauss & Union Station also won three awards; and Kelly Clarkson won two. Green Day were amongst the big winners, winning the Grammy Award for Record of the Year.

U2 was the night's top winner, with five awards. Their win for Album of the Year was their second win for that particular award. They previously won it back in 1988 for The Joshua Tree. They are the only rock act to have more than one Album of the Year win.

Top nominees included Mariah Carey, John Legend and Kanye West with eight each, but won only three awards each. Kelly Clarkson won two awards, becoming the first American Idol contestant ever to win a Grammy.

Multiple award winners (awards won/nominated):

Awards for composing and arranging:

Awards for soundtrack contributions:

Award for Musical theatre recording:

Awards for production and engineering: