ALDH1L2

ALDH1L2
Identifiers
Aliases	ALDH1L2, mtFDH, aldehyde dehydrogenase 1 family member L2
External IDs	OMIM: 613584; MGI: 2444680; HomoloGene: 51942; GeneCards: ALDH1L2; OMA:ALDH1L2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	105,107,643 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	83,370,004 bp
RNA expression pattern
	Top expressed in
	tibia; ; body of pancreas; ; stromal cell of endometrium; ; pancreatic epithelial cell; ; parotid gland; ; Achilles tendon; ; tendon of biceps brachii; ; islet of Langerhans; ; bone marrow cell; ; Descending thoracic aorta;
	Top expressed in
	parotid gland; ; calvaria; ; lacrimal gland; ; body of femur; ; fossa; ; submandibular gland; ; atrium; ; umbilical cord; ; pancreas; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydroxymethyl-, formyl- and related transferase activity; formyltetrahydrofolate dehydrogenase activity; oxidoreductase activity; catalytic activity; aldehyde dehydrogenase (NAD+) activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;
Cellular component	extracellular exosome; cytoplasm; mitochondrion; mitochondrial matrix; nucleus;
Biological process	one-carbon metabolic process; biosynthesis; 10-formyltetrahydrofolate catabolic process; metabolism; folic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	160428
	216188
	ENSG00000136010
	ENSMUSG00000020256
	Q3SY69
	Q8K009
	NM_001034173
	NM_153543
	NP_001029345
	NP_705771
	Wikidata
View/Edit Human	View/Edit Mouse

Aldehyde dehydrogenase 1 family, member L2 also known as ALDH1L2 is an enzyme that in humans is encoded by the ALDH1L2 gene.^[5]^[6] ALDH1L2 is the mitochondrial isoform of a similar enzyme, ALDH1L1, which converts 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136010 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020256 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ Ota T, Suzuki Y, Nishikawa T, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
^ Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA. "ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase." J Biol Chem. 2010 Jul 23;285(30):23056-63.
^ Strickland KC, Krupenko NI, Dubard ME, Hu CJ, Tsybovsky Y, Krupenko SA. "Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahdyrofolate dehydrogenase." Chem Biol Interact. 2011 May 30;191(1-3):129-36.

External links

Human ALDH1L2 genome location and ALDH1L2 gene details page in the UCSC Genome Browser.

v t e Aldehyde dehydrogenases (EC 1.2.1)
Family 1	Retinaldehyde — ALDH1A1 ALDH1A2 ALDH1A3 ALDH1B1 Formyltetrahydrofolate — ALDH1L1 ALDH1L2
Family 2 (mitochondrial)	ALDH2
Family 3	Dimeric NADP-preferring — (ALDH3A1) Fatty aldehyde — (ALDH3A2) ALDH3B1 ALDH3B2
Other	ALDH4A1 ALDH5A1 ALDH6A1 α-Aminoadipic semialdehyde — (ALDH7A1) ALDH8A1 ALDH9A1 ALDH16A1 ALDH18A1 Glyceraldehyde 3-phosphate — (GAPDH)

ALDH1L2

ALDH1L2

ALDH1L2

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ALDH1L2

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