Early in her career, Almutairi developed chemically amplified response (CAR) polymers. These polymers, capable of dramatically changing their properties in response to small stimuli, formed the basis for many of her subsequent innovations in drug delivery and imaging.

Almutairi's research has consistently focused on the development of innovative nanomedicine and drug delivery systems. She has explored methods for targeting specific tissues and cells, controlling drug release, and enhancing the effectiveness of therapies.

A significant aspect of Almutairi's research involves the creation of advanced imaging technologies, allowing for better visualization and monitoring of biological processes. Her work has led to improved diagnostic tools and a deeper understanding of disease mechanisms.