The Kingdom of Greater Armenia or simply Greater Armenia or Armenia Major (Armenian: Մեծ Հայք Mets Hayk; Latin: Armenia Maior), sometimes referred to as the Armenian Empire under Tigranes II, was an Armenian kingdom in the Ancient Near East which existed from 331 BC to 428 AD. Its history is divided into the successive reigns of three royal dynasties: Orontid (331–200 BC), Artaxiad (189 BC – 12 AD), and Arsacid (52–428).

The root of the kingdom lies in the Satrapy of Armenia of the Achaemenid Empire of Iran, which was formed from the territory of Urartu (860–590 BC) after it was conquered by the Medes in 590 BC. The satrapy became a kingdom in 321 BC during the reign of the Orontid dynasty after the conquest of Persia by Alexander the Great, which was then incorporated as one of the Hellenistic kingdoms of the Seleucid Empire.

Under the Seleucid Empire (312–63 BC), the Armenian throne was divided in two—Greater Armenia and Sophene—both of which passed to members of the Artaxiad dynasty in 189 BC. During the Roman Republic's eastern expansion, the Kingdom of Armenia, under Tigranes the Great, reached its peak, from 83 to 69 BC, after it reincorporated Sophene and conquered the remaining territories of the falling Seleucid Empire, effectively ending its existence and raising Armenia into an empire for a brief period, until it was itself conquered by Rome in 69 BC. The remaining Artaxiad kings ruled as clients of Rome until they were overthrown in 12 AD due to their possible allegiance to Rome's main rival in the region, Parthia.

During the Roman–Parthian Wars, the Arsacid dynasty of Armenia was founded when Tiridates I, a member of the Parthian Arsacid dynasty, was proclaimed King of Armenia in 52. Throughout most of its history during this period, Armenia was heavily contested between Rome and Parthia, and the Armenian nobility was divided among pro-Roman, pro-Parthian or neutral factions. From 114 to 118, Armenia briefly became a province of the Roman Empire under Emperor Trajan. The Kingdom of Armenia often served as a client state or vassal at the frontier of the two large empires and their successors, the Byzantine and Sassanid empires. In 301/314, Tiridates III proclaimed Christianity as the state religion of Armenia, making the Armenian kingdom the first state in history to embrace Christianity officially.

In 387, Armenia was partitioned into Byzantine Armenia and Persian Armenia. The last Arsacid king of Armenia was deposed in 428, ending independent Armenian statehood until the emergence of Bagratid Armenia in the 9th century.

Prior to the 9th century BC, the geographic region known as the Armenian Highlands was inhabited by Proto-Armenian and other tribes which did not yet constitute a unitary state or nation. The first state to rule over a significant part of the Armenian Highlands was the Kingdom of Urartu, also known as the Kingdom of Van or Ararat and called Biainili in the Urartian language used by its rulers. The kingdom competed with Assyria over supremacy in the highlands of Ararat and the Fertile Crescent.

Both kingdoms fell to Iranian invaders from the east (the Medes, followed by the Achaemenid Persians) in the 6th century BC. Its territory was reorganized into a satrapy called Armenia. The Orontid dynasty ruled as satraps of the Achaemenid Empire for three centuries until the empire was defeated by Alexander the Great's Macedonian Empire at the Battle of Gaugamela in 331 BC. After Alexander's death in 323 BC, a Macedonian general named Neoptolemus obtained Armenia until he died in 321 BC and the Orontids returned, not as satraps, but as kings.

Orontes III and the ruler of Lesser Armenia, Mithridates, recognized themselves independent, thus elevating the former Armenian satrapy into a kingdom, giving birth to the kingdoms of Armenia and Lesser Armenia. Orontes III also defeated the Thessalian commander Menon, who wanted to capture Sper's gold mines.