The Belgrade Main Railway Station (Serbian: Железничка станица Београд Главна, romanized: Železnička stanica Beograd Glavna) is a former train station in Belgrade, the capital of Serbia. It was built between 1882 and 1885 according to the designs of the architect Dragutin Milutinović, and it has the status of a сultural monument of great importance. Until the opening of the new Belgrade Center station (Prokop) in 2016, it was the city's main station, and the busiest in the country. In order to free up the space for the Belgrade Waterfront project, the station was closed on 1 July 2018, and repurposed to become a museum.

Passenger trains were gradually relocated to the new Prokop station during 2016 and 2017. Most national railway traffic was moved to the new station in December 2017, thus leaving only international trains and two trains to Novi Sad at the old station. The Main station operated until 30 June 2018, when the last train, international train 340 to Budapest, left the station at 21:40. International trains were relocated to Prokop and trains to Bar relocated to the Topčider railway station.

At the 1878 Congress of Berlin the Principality of Serbia was de jure recognized as an independent state. The great powers of the day decided that Serbia should construct a railway. Not economically developed to begin with, Serbia was additionally pauperized after the Serbian-Ottoman wars from 1876 to 1878, so it lacked the necessary funds. Prince Milan Obrenović and the government announced a request for tender and the bidding was won by a French company. According to a popular - but unproven - version of events, Prince Milan accepted a bribe of 1 million francs in gold to give the job to the French.

The concession included the construction of the Belgrade–Niš railway, the train bridge over the Sava river and a railway that would connect Belgrade to Zemun, a border town of Austria-Hungary at the time. The location of the future station building was chosen in 1881. It was a marshy bog called Ciganska bara ("Gypsy pond"). The bog was charted for the first time in an Austrian map from 1789. It was a marsh which covered a wide area stretching from the present-day Karađorđeva street to the mouth of the Topčiderska Reka into the Sava, across the northern tip of Ada Ciganlija. The marshy area covered the today's location of the Belgrade Main railway station and parts of the Sarajevska and Hajduk-Veljkov venac streets. Ciganska bara drained two other bogs. One was located on Slavija, which drained through the creek of Vračarski potok which flew down the area of the today's Nemanjina Street. The other pond was Zeleni Venac. The eponymous Gypsies inhabiting the area used the mud from the bog to make roof tiles. They lived in small huts or caravans (called "čerge"), between the high grass and rush, with their horses and water buffalos grazing freely in the area. As most of the huts were actually stilt houses built on piles due to the marshy land, the area was gradually named Bara Venecija ("Venice pond").

As such, the location was inappropriate for any construction work and the marsh had to be filled first. The remains of the demolished Stambol Gate in 1866 also finished in the bog. By 1884 the bog was drained and buried under the rubble from all parts of the city but especially from Prokop, Prokop is located in the eastern section of the former neighborhood of Jatagan Mala. Previously, it was a geographical reference, as the area was located in the lower valley of the now-underground stream of Mokroluški Potok. Earth and gravel were dug and used to cover and drain the swamps on the right bank of the Sava, so that the neighborhoods of Savamala and Bara Venecija could be constructed, along with the building of central railway station. After the works were completed, the area around Mokroluški Potok was left as a steep, elongated cut in the ground, thus acquiring its name (Serbian prokop, cut or dug through). Prince Milan personally suggested this area, which stretched above Đorđe Vajfert's brewery and the neighborhood of Smutekovac. Among his many reasons he cited the quality of the earth and the fact that the proximity of the construction site would reduce the transportation costs. However, that land belonged to his wife, Princess Natalie, so the prince even earned money from the station's construction. In a historical twist, Prokop is the location of Belgrade's designated present-day central railway station.

When the location was chosen, it was also disconnected from Belgrade in terms of transportation. The former village of Savamala was closest, but the city could only be reached using a fiaker, and this along a bypass route leading through Spomenička Street (modern Nemanjina).

The construction of the railway and station initially met with fierce opposition. The law on railway construction barely passed in the National Assembly of Serbia, while for the railway itself it was said that it was both costly and unnecessary; a "devil's snake"; a "destroyer of the people", a threat to female fertility and a conduit of infiltration by foreign powers.

The foundation stones were laid by prince Milan: for the railway on 3 July [O.S. 21 June] 1881, for the station on 15 April [O.S. 3 April] 1883. The building of the station lagged behind the construction of the railway and the bridge, so when the time came for the first train to pass through Belgrade, the object wasn't finished. As it was obvious that the station won't be finished on time, the temporary object was built to serve the purpose instead. Even though at one point in 1884 it was recorded that 5,575 workers were employed on the building's construction, it couldn't be finished in time. It had to be ceremonially open, even though it was still covered with scaffolds. The first train from this station departed towards Zemun with courtly honours, on 1 September [O.S. 20 August] 1884, at 3 p.m. As Serbia was declared a kingdom in 1882, the first passengers were now King Milan, Queen Natalie and the Crown Prince Alexander, on the way to Vienna. More than 200 foreign guests and couple of thousands of citizens attended the opening ceremony.