Biker Mice from Mars is an American animated series created by Rick Ungar. The series premiered in syndication the week of September 19, 1993. It consists of three seasons of 65 episodes, with the final episode airing in syndication the week of February 24, 1996.

The show follows three anthropomorphic mice motorcyclists named Throttle, Modo, and Vinnie who escape a war on their home planet Mars before arriving to rebel on the Earth against the species that destroyed their homeland (the Plutarkians). The mice's signature weapons consist of a cestus and a laser pistol (Throttle), a bionic arm with built-in laser blaster (Modo), and flares (Vinnie). Despite the frequent battles, no blood is shown, and many villains are monsters, aliens, and robots.

Ownership of the initial Biker Mice TV series passed to Disney in 2001 when Disney acquired Fox Kids Worldwide, which also includes Marvel Productions.

On the planet Mars, there existed a race of anthropomorphic mice who enjoyed motorsports and had a very similar culture and society to that of human beings. At some point in time they were all but wiped out by the Plutarkians, alien fish-like humanoids who plunder other planets' natural resources because they have wasted all of their own. Three survivors, Throttle, Modo and Vinnie, manage to escape on a spaceship, but are shot down by a Plutarkian warship and crash-land on Earth in the city of Chicago. There they meet a charming female mechanic named Charlene "Charley" Davidson and discover that the Plutarkians have come to Earth to steal its natural resources.

The Biker Mice investigate the crumbling ghetto of the windy city and soon discover that Chicago's leading industrialist, Lawrence Limburger, is actually a Plutarkian who disguises himself as a human, plotting to ransack Earth's resources to send to his own dying planet. Limburger enlists two henchmen, mad scientist Dr. Karbunkle and the idiotic Greasepit, to help him steal Earth's natural resources and send them to Plutark with the help of some supervillains that they transport from another location in the galaxy. The Biker Mice become destined to stop Limburger's schemes. The most frequent sign of victory is destroying Limburger's tall tower, forcing him to constantly spend money and time to rebuild it by the next episode.

In most episodes, Limburger orders Karbunkle to use the transporter to bring into Chicago one of the very powerful supervillains in the universe. Generally each of them have one special ability which is useful for Limburger's plan in hand. Most of them seem to use an asteroid station called Black Rock as their main hideout when they are not summoned by those willing to pay for their services. On one notable occasion in the episode "A Scent, a Memory, a Far Distant Cheese", Limburger and Karbunkle accidentally got sucked into the transporter and appear at the Black Rock where all the villains up to that episode confront him for not paying them as they asked for. The episode "Diet of Worms" shows that the other Plutarkians can use the same supervillains.

The following supervillains are listed in order of appearance:

The series has been aired from 1993 to 1996 in the United States on many first-run syndicated affiliates.