Hamrun (Maltese: Ħamrun [ħɐmˈruːn]) is a town in the Southern Region of Malta, with a population of 9,244 as of March 2014.

The townspeople are traditionally known as Tas-Sikkina (literally meaning 'of the knife' or 'those who carry a knife') or as Ta' Werwer (which literally means 'those who scare' or more colloquially, 'the scary ones'). This appellation could stem from the fact that a considerable number of Ħamruniżi used to work as stevedores on the docks and thus carried a knife at all times. Another theory was that the community of Sicilians who settled here illegally in the 16th century danced a traditional dance which involved the wielding of small stilettos which they carried in their socks, waving them in the air and back to their sheaths.

Although born in Valletta, George Preca (founder of the Society of Christian Doctrine) lived most of his life in Hamrun. He is buried in a Chapel in Hamrun. It is the home town of former Prime Minister Karmenu Mifsud Bonnici and of Presidents Anton Buttigieg and Guido de Marco. The founder of the Malta Workers' Union (UHM), Salvino Spiteri, was born and lived here.

Hamrun gave birth to several important artists and men of letters. Notable persons from Hamrun are the actor and lyrical singer Oreste Kirkop, who is remembered mostly for his role in the 1956 Hollywood film The Vagabond King, and Maltese poet and theatre director Mario Azzopardi (born in 1944), who has a strong reputation for introducing new, radical poetry in Malta in the Sixties and who became the artistic director of the Malta Drama Centre (est. 1979). Josephine Zammit Cordina is a well-known actress and TV personality. She is also associated with Australia being the presenter of the Radio Programme "Boomerang" and TV programme "Waltzing Matilda". She was honoured by the Government of Malta (Ġieħ Ir-Republika) and the Government of Australia (Honorary Member of the Order of Australia). Il-Kavallier tal-Irkotta. Joe Zammit Cordina (Josephine's brother in-law) was also a well-known actor and TV personality. He took part in a number of International Films in minor character roles. The Airport scene in "Midnight Express" is well remembered. He was also Mayor of Hamrun.

Another modern poet, Victor Fenech (b. 1936), involved for many years as a drama critic, also hails from Hamrun. From the romantic school of literature one should mention Rev. Frans Camilleri, also born in this town. Hamrun also gave birth to film director Mario Philip Azzopardi (born in 1950), who is not to be confused with Mario Azzopardi^{[permanent dead link]} the poet and drama animator (also born in Hamrun in 1944). Mario Philip settled in Canada and has many commercial film titles and TV serials to his credit. The other Mario Azzopardi is a well-known poet and animator, accredited with introducing new forms of literature to the island.

Joseph Buttigieg, distinguished literary scholar at the University of Notre Dame and father of South Bend, Indiana mayor and United States Secretary of Transportation Pete Buttigieg, was born in Hamrun.

Hamrun is also the home town of playwright Oreste Calleja (b. 1946), an acclaimed author who wrote important new-genre plays in the native language.

Hamrun has also been the home for a number of years of Bjorn Formosa M.Q.R, the ALS Malta founder, who in 2017 was also honoured with Ġieħ il-Ħamrun.