Bolton Interchange is a transport interchange combining Bolton railway station and Bolton bus station in the town of Bolton, in Greater Manchester, England. It is a stop on the Manchester to Preston and Ribble Valley lines; it lies 11+1⁄4 miles (18.1 km) north-west of Manchester Piccadilly. The station is managed by Northern Trains, which operates services along with TransPennine Express.

The railway station was originally named Bolton Trinity Street to differentiate it from nearby Bolton Great Moor Street station, which closed in 1954. The station was also known as Bridgeman Street and Bradford Square.

There are frequent local and semi-fast services to Manchester Victoria, Manchester Oxford Road, Manchester Piccadilly, Clitheroe, Blackburn, Wigan Wallgate, Blackpool North and Barrow-in-Furness. Services operating to Victoria and Piccadilly operate through and terminate at other regional stations, such as Manchester Airport and Stalybridge. Inter-city services to Edinburgh Waverley and Glasgow Central stop at Bolton.

Trinity Street station opened when the Manchester and Bolton Railway completed its route to Salford Central in 1838. The line was extended to Manchester Victoria in 1843. This line was extended to Preston by the Bolton and Preston Railway in 1841. The route northwards, now the Ribble Valley Line, to Blackburn followed four years later, whilst the Liverpool and Bury Railway's arrival in 1848 gave the town links eastward to Bury and Rochdale, and westwards to Wigan and Liverpool. These lines had all become part of the Lancashire and Yorkshire Railway system by 1858.

The network of routes radiating from Bolton has remained largely unchanged to this day, the one exception being the line to Rochdale which closed on 5 October 1970. Through trains to Liverpool ended in 1977 with the closure of Liverpool Exchange, but the line to Wigan remains open. Trains to Manchester Piccadilly and beyond began in May 1988 with the opening of the Windsor Link.

Automatic ticket barriers have been operational at the station since 12 December 2016. Northern (Arriva Rail North Limited) had announced its intention to install them here (and at several other locations) earlier in the year.

The entrance and ticket office are at street level, at which there is a footbridge to the bus station and the taxi rank. A walkway leads to the platforms which are in a cutting. Platforms 1 and 3 have a buffet, a large waiting room and toilets. Platforms 4 and 5 have a small waiting room with toilets.

Parking facilities here were closed permanently on 24 January 2017.