List of Days of Our Lives characters introduced in the 2000s

Days of Our Lives is an American soap opera broadcast on the NBC network. Created by Ted and Betty Corday, the series focuses on the residents of the fictional midwestern town of Salem, USA. It premiered on November 8, 1965. This is a list of notable characters who significantly impacted storylines and made their first appearance between 2000 and 2009.

J.T. Reiber, born on June 9, 2000, is introduced as the child intended to be adopted by Abe Carver (James Reynolds) and Lexie Carver (Renée Jones). However, Lexie's father Stefano DiMera (Joseph Mascolo) switches the infant at birth with Bo and Hope's (Peter Reckell and Kristian Alfonso) son. After years of trying for a baby the natural way, Abe and Lexie Carver decide that they will adopt a child. When Lexie's father Stefano DiMera hears about the news, he is over joyed at the prospect of finally becoming a grandfather and asks that Abe and Lexie adopt the child of one of his distant relatives. The birth mother Marlo is in fact the niece of Dr. Rolf, Stefano's longtime assistant. However, none the wiser to Lexie and Abe, Stefano is planning a plot whereby Marlo's baby would be switched with the baby of Bo and Hope's who Stefano at the time thought might be his or John Black's. After the births of the babies, Stefano has Dr. Rolf switch Hope's and Marlo's babies birth tags. So, the baby is instead taken home by Bo and Hope Brady and named John Thomas, getting his names from family friend John Black (Drake Hogestyn) and Hope's late grandfather Tom Horton (MacDonald Carey).

He was later reclaimed by his birth father Glen Reiber and new wife Barb.

Zack Brady was the second son and child of supercouple Hope and Bo Brady, born June 9, 2000. For the longest time, Zack is known as Isaac Theo Carver, the long-awaited and much-beloved son of Abe and Lexie Carver. For years the two had tried unsuccessfully to have a child of their own with no success, until Lexie's father, Stefano, got them in touch with Marlo, a young pregnant woman. Abe and Lexie adopt the baby that Marlo has given birth to, unaware that Stefano had switched Marlo and Hope's sons.

Zack dies on January 1, 2006, after being run over by Bo's SUV, which is driven by his daughter, Chelsea. Upon his death, his liver is donated to his niece, Claire Brady, and his corneas are donated to Abe Carver; Claire's life is saved and Abe regains his eyesight. Zack's death and the revelation of Chelsea as the SUV driver drive a wedge between Bo and Hope – as well as the rest of the Brady family for most of 2006.

In June 2016, Hope has a vision of a teen Zack at the age he would have been, had he lived, portrayed by Scott Shilstone.

Shilstone returned to the role in Days of Our Lives: Beyond Salem as an angel to help Bo to convince his mom to return to Earth to help their family. In September 2023, his sister Chelsea returns to Salem for their grandfather Victor Kiriakis' funeral and she announced that she gave birth to her and Max Brady's son, whom they have named Issac after Zack. Brandon Butler will assume the role in June 2025, when Zack appears once more to Bo.

Bonnie Lockhart is the mother of Patrick, Mimi, and Conner Lockhart. The role was originated by Robin Riker, who played the role from July 11 to 31, 2000. Kathy Connell then played the role from August 15, 2000, to June 7, 2002. Judi Evans, who previously played Adrienne Johnson Kiriakis, took over the role the following year; she is the most notable actress to play the role and has had the longest tenure. Evans played Bonnie from September 1, 2003, to March 1, 2007. A decade later, Bonnie returned to the show on July 21, 2017, when Evans was also portraying Adrienne Kiriakis. The character departed again on October 25, 2017, then returned on August 20, 2018, and remained on the show until November 6 of that year.