Pitt was in a relationship with actress Gwyneth Paltrow for approximately three years.

He married actress Jennifer Aniston in 2000, but they divorced in 2005 after five years of marriage.

Pitt met Angelina Jolie on the set of "Mr. & Mrs. Smith" and they were in a relationship until their divorce in 2019. They adopted several children together: Maddox (2002), Pax (2003), and Zahara (2005), and had biological children: Shiloh (2006), Knox (2008), and Vivienne (2008).