Coronation Street is a British soap opera first broadcast on ITV on 9 December 1960. This is a list of characters that will make their first appearance in 2025. The first character to appear in January was Mandy Waring (Rebecca Atkinson), a prison guard who had a brief relationship with Rob Donovan (Marc Baylis) and helped him escape from prison. She was followed by Brie Benson (Jessica Ellis), the cellmate of Lauren Bolton (Cait Fitton), and Steven Poyser (Samuel James). A new family consisting of Lou (Farrel Hegarty) and Mick Michaelis (Joe Layton) debuted in February. They were followed in March by Lou's son Brody (Ryan Mulvey), who is cellmate of Dylan Wilson (Liam McCheyne). Later in March, Theo Silverton (James Cartwright) arrived as a new love interest for Todd Grimshaw (Gareth Pierce) and Laila Bailey, the daughter of Dee Dee Bailey (Channique Sterling Brown) and Joel Deering (Calum Lill). In April, Wes Fuller (Kevin Finn) made his first appearance, followed by Danielle Silverton (Natalie Anderson), the wife of Theo. Carl Webster, the half-brother of Kevin (Michael Le Vell) and Debbie Webster (Sue Devaney), also made his first appearance in April 2025. Additionally, several other characters appeared throughout the year.

Mandy Waring, played by Rebecca Atkinson, is a prison guard who appeared in scenes with Rob Donovan (Marc Baylis) and Matty Radcliffe (Seamus McGoff). She first appeared on 13 January 2025. Upon her first appearance, she was held hostage by Matty alongside Rob and his son, Bobby Crawford (Jack Carroll), who was visiting him. A source said: "Rebecca is a hugely talented actress and she's a great addition to the cast. She's joined for a short stint and will be on screen for a few months while the storyline she's involved with plays out." This was Atkinson's second role in Coronation Street after playing Stephanie Mills in 2002.

Brie Benson, played by Jessica Ellis, made her first appearance on 15 January 2025 as an inmate in prison where Lauren Bolton (Cait Fitton) is serving time for the murder of Joel Deering (Calum Lill). Ellis' guest role was announced on 7 January 2025 and is expected to last several episodes. Stefania Sarrubba from Digital Spy revealed: "The details of Ellis' stint on the cobbles are being kept under wraps, but we know her character Brie won't go easy on Lauren." Sarrubba also revealed: "As Lauren's trial begins, Brie tells her that her baby son Frankie would be better off without her." James Hibbs from Radio Times revealed that Brie would be seen "purposefully antagonising her in prison."

Ellis made her final appearance on 20 January 2025 and announced her departure on Instagram saying: "Well I had to get a picture in that iconic coat didn't I?" and "As a Manchester gal, what a moment in my career to get to be in the most iconic soap that I grew up with Coronation Street."

Lou Michaelis, portrayed by Farrel Hegarty, made her first appearance on 12 February 2025 as part of Coronation Street's new family. She and her husband, Mick Michaelis (Joe Layton), were announced in December 2024, with it being explained that Mick and Lou are a married couple that would first connect with established character Chesney Winter-Brown (Sam Aston) as they would come to live nearby him at the fictional Mawdsley Street, which is nearby to Coronation Street. Brooks described Mick and Lou as "livewires" and "ruffians" that would cause a lot of damage, chaos and trouble, and teased that they would open up the "floodgates" and explore the backstory of established character Kit Green (Jacob Roberts). Brooks revealed that she and the team were very excited by their arrival, explaining, "They come in with oodles of drama and they are shaking things up. They're neighbours from hell. They're overfamiliar, likeable and they've got kids. Initially they develop a friendship with Chesney and [his wife] Gemma (Dolly-Rose Campbell), but there are other things to unpack. I wouldn't want to get on the wrong side of them – especially Mick!" She also teased that they would come in "all guns blazing" and leave a "a trail of devastation", but called them "really enjoyable", adding, "They have a charm to them, but they do and say things that you shouldn't!" Whilst the pair's casting was not revealed at the time of the announcement, Brooks believed that the characters were portrayed by "brilliant actors". Following Mick and Lou's debuts, Chloe Timms from Inside Soap joked that she was happy to watch the couple as long as she did not have to "live next door to them".

On 30 January 2025, it was announced that Hegarty would be playing the role of Lou alongside Joe Layton, who would portray Mick. Her and Mick have been billed as a "nightmare couple", with Daniel Kilkelly from Digital Spy describing them to be a "chaotic couple". It has also been revealed that Lou will strike up a friendship with who recognise each other from Bessie Street School, where Lou's two daughters attend alongside Gemma Winter-Brown's (Dolly-Rose Campbell) quads. Kilkelly also revealed: "Show bosses have warned that Coronation Street's residents should watch their backs, as Mick and Lou will make life difficult for anyone who crosses them." Kilkelly also revealed that the pair also have a connection with Gemma's half-brother Kit Green (Jacob Roberts). Hegarty spoke about her casting: "I'm delighted and so grateful to be joining the cast of Coronation Street. I have genuinely been blown away by how ridiculously warm and nice everyone is. Lou is definitely an exciting character to play because she's got good and bad parts to her, she's a life force and full of beans. She's a very colourful person who likes to make waves and try to cause chaos. But she also has that strong family loyalty, especially between Mick and Lou. They are thick as thieves and will stick up for each other, even when they probably shouldn't." Coronation Street executive producer, Kate Brooks also spoke about their castings: "Chaotic and loud, Mick and Lou bulldoze their way into Weatherfield, causing absolute carnage for the residents of Coronation Street. Their relationship is volatile to say the least, but at the heart of it lies a fierce sense of family loyalty, and woe betide anyone who tries to come between them. Although they're the life and soul of any party, they're equally not everyone's cup of tea, and they soon find themselves at the root of some explosive drama. We're thrilled to introduce these new characters into the mix, and the cobbles certainly won't be quiet with this family around."

On 10 March 2025, it was announced that Lou would appear in flashback scenes to 2007 which show Bernie Winter (Jane Hazlegrove) trying to make contact with her son Kit, who she gave up for adoption after he was born. In these scenes, it was announced that Charlotte Alex-Riley would play the younger version of Lou.

On 31 March 2025, it was announced that Hegarty would be leaving the role of Lou with her on-screen husband Mick, whose departure was announced one week prior. Lou and Mick are set to depart after a "major storyline". A Coronation Street insider confirmed both exits: "Mick and Lou were brought into the show to cause chaos on the cobbles in the build up to a major storyline in the summer and they are already making their presence felt. Joe and Farrel were contracted for a specific length of time, some characters come in for a long time and some like Mick and Lou are brought to pass through and leave a trail of destruction behind them. Both actors are still filming with the show and will be on screen until the summer."