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Calmodulin-binding transcription activator 1

Calmodulin-binding transcription activator 1

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Calmodulin-binding transcription activator 1

CAMTA1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CXK

Identifiers

CAMTA1, CANPMR, calmodulin binding transcription activator 1

External IDs

OMIM: 611501; MGI: 2140230; HomoloGene: 18942; GeneCards: CAMTA1; OMA:CAMTA1 - orthologs

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[1]

Band	4\|4 E2	Start	150,917,322 bp^[1]
Band	4\|4 E2	End	151,861,876 bp^[1]

RNA expression pattern

Human

Mouse (ortholog)

n/a

Top expressed in

ventromedial nucleus

superior colliculus

inferior colliculi

mammillary body

lateral septal nucleus

lateral hypothalamus

central gray substance of midbrain

dorsomedial hypothalamic nucleus

paraventricular nucleus of hypothalamus

cerebellar cortex


More reference expression data

Gene ontology
Molecular function	sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	nucleus nucleolus cytoplasm cytosol
Biological process	regulation of transcription, DNA-templated neuromuscular process controlling balance transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II positive regulation of protein dephosphorylation positive regulation of calcineurin-NFAT signaling cascade
Sources:Amigo / QuickGO

Species

Human

Mouse


23261


100072


ENSG00000171735


ENSMUSG00000014592


Q9Y6Y1


A2A891

RefSeq (mRNA)


NM_001195563 NM_001242701 NM_015215


NM_001081557 NM_001166021 NM_001195565

RefSeq (protein)

NP_001182492 NP_001229630 NP_056030 NP_001336537 NP_001336538
NP_001336539 NP_001336541 NP_001336542 NP_001336543 NP_001336544 NP_001336545 NP_001336546 NP_001336547 NP_001336548 NP_001336549 NP_001336550 NP_001336551 NP_001336552 NP_001336553 NP_001336554 NP_001336555 NP_001336556


NP_001075026 NP_001182494

Location (UCSC)

n/a

Chr 4: 150.92 – 151.86 Mb

PubMed search

^[2]

^[3]

View/Edit Human

View/Edit Mouse

Calmodulin-binding transcription activator 1 is a protein that in humans is encoded by the CAMTA1 gene.^[4]^[5]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014592 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bouche N, Scharlat A, Snedden W, Bouchez D, Fromm H (Jun 2002). "A novel family of calmodulin-binding transcription activators in multicellular organisms". Journal of Biological Chemistry. 277 (24): 21851–61. doi:10.1074/jbc.M200268200. PMID 11925432. S2CID 9090244.
^ "Entrez Gene: CAMTA1 calmodulin binding transcription activator 1".

Further reading

Katoh M, Katoh M (2004). "Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23". International Journal of Oncology. 23 (4): 1219–24. doi:10.3892/ijo.23.4.1219. PMID 12964007.
Nakatani K, Nishioka J, Itakura T, et al. (2004). "Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells". Int. J. Oncol. 24 (6): 1407–12. doi:10.3892/ijo.24.6.1407 (inactive 11 July 2025). PMID 15138581.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
Barbashina V, Salazar P, Holland EC, et al. (2005). "Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene". Clinical Cancer Research. 11 (3): 1119–28. doi:10.1158/1078-0432.1119.11.3. PMID 15709179.
Henrich KO, Claas A, Praml C, et al. (2007). "Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma". European Journal of Cancer. 43 (3): 607–16. doi:10.1016/j.ejca.2006.09.023. PMID 17222547.
Huentelman MJ, Papassotiropoulos A, Craig DW, et al. (2007). "Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance" (PDF). Human Molecular Genetics. 16 (12): 1469–77. doi:10.1093/hmg/ddm097. PMID 17470457.

v t e PDB gallery
2cxk: Crystal structure of the TIG domain of human calmodulin-binding transcription activator 1 (CAMTA1)

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