Casemiro played for São Paulo FC, making 112 appearances and scoring 11 goals.

Casemiro was loaned to Real Madrid for the remainder of the 2012-13 season.

Casemiro was loaned to Porto for the 2014-15 season, where he made 41 appearances and scored 4 goals.

Casemiro became an integral part of Real Madrid's team, winning multiple trophies including five UEFA Champions Leagues and three La Liga titles.

Casemiro joined Manchester United on a four-year contract for a fee of £60 million, plus £10 million in add-ons.