From an early age, Lindbergh showed a natural aptitude for mechanics. He loved tinkering with machines and engines, demonstrating a deep curiosity about how things worked. This curiosity led him to pursue a career in aviation.

Lindbergh played a crucial role in the design of the 'Spirit of St. Louis'. He worked closely with Ryan Airlines to ensure the aircraft was optimized for the transatlantic flight, focusing on lightweight construction, fuel efficiency, and reliability.

Lindbergh collaborated with Dr. Alexis Carrel, a Nobel Prize-winning surgeon, to develop a perfusion pump, a precursor to the artificial heart. Their work aimed to keep organs alive outside the body for research and transplantation. Although the technology was not fully successful at the time, it laid groundwork for later advancements in cardiac surgery.

During World War II, Lindbergh used his knowledge of aerodynamics and engine performance to improve the efficiency and range of fighter aircraft. He developed techniques for fuel conservation that were adopted by pilots, significantly enhancing their combat capabilities.

After the war, Lindbergh consulted with airlines and the U.S. Air Force on the development and implementation of jet aircraft. He contributed to improving jet engine efficiency, air traffic control systems, and overall air safety.