Charlize Theron was appointed as a United Nations Messenger of Peace, with a focus on advocating for the prevention of HIV and ending violence against women.

Theron founded the Charlize Theron Africa Outreach Project (CTAOP), which supports African adolescent youth in the fight against HIV/AIDS. The project focuses on South Africa.

CTAOP supports various programs focused on HIV prevention, sexual health education, and life skills training for young people in Southern Africa.

Charlize Theron received the GLSEN (Gay, Lesbian & Straight Education Network) Humanitarian Award for her advocacy for LGBT rights.

Theron has been a vocal advocate for women's rights, gender equality, and an end to violence against women.

CTAOP partnered with UNAIDS to strengthen HIV prevention efforts in South Africa.

Theron regularly participates in speaking engagements and awareness campaigns to promote her philanthropic causes and advocate for social change.