Christ the King Regional High School is a co-educational, college preparatory, Catholic high school for grades 9–12 located in Middle Village, Queens, New York, United States and established in 1962. It is located within the Roman Catholic Diocese of Brooklyn. The school is next to the Middle Village–Metropolitan Avenue station of the New York City Subway's M train.

Originally built and operated by the Roman Catholic Diocese of Brooklyn as a diocesan high school, Christ the King High School began with its first freshman class starting September 1962 with its teachers at Mater Christi High School in Astoria, Queens. The first classes at the unfinished Middle Village location were held on May 6, 1963 and the school building was dedicated in April 1964.

At its start, Christ the King was organized into separate boys and girls divisions staffed by two religious orders of Marist Brothers and Daughters of Wisdom. The two divisions occupied opposite wings of the building and shared its library, cafeteria and auditorium. The top floors of the separate wings were designed and built as residential facilities to accommodate the two religious orders living areas.

The first graduation took place on June 23, 1966 with 840 graduates, exactly split between 420 boys and girls. Attendance at all of the Brooklyn Diocese operated high schools was free until September 1968 when it initiated a $300 tuition charge.

By 1970, the enormous changes underway in Catholic religious orders compelled the Sisters of Wisdom to withdraw from staffing the Girls Division and coeducational classes were started to transition into merging the two divisions. In September 1971, Mr. Hugh Kirwan became the first lay Principal of the Girl's Division. In 1972 the Marist Brothers announced they would be ending their connection with the school.

In September 1973 Mr. Kirwin was appointed to run a unified school at a time of serious discord with the rapidly expanding lay faculty that delayed opening of classes for one week. After two years of futile negotiations, no contract was signed and in October 1975 the Bishop announced that Christ the King High School would be closed and seniors would be allowed to finish there, but all other students would be transferred to other diocesan schools.

The diocese plan outraged the students and supported by their families, they went on strike and refused to vacate the building. Discussions between the school supporters and the diocese finally resulted in September 1976 becoming Christ the King Regional High School.

The school offers various honors and Advanced Placement classes. Select students have received outstanding PSAT and SAT scores. Numerous students have been accepted into prestigious schools, such as Yale, UPenn, Fordham University, Johns Hopkins University, and Macaulay Honors College and receive substantial scholarships to lesser prestigious institutions. Admission is based upon 6th, 7th, and 8th grade records, as well as the TACHS exam.