Constantijn Huygens played a significant role in Christiaan's life, fostering his education, providing connections to influential figures, and managing his financial affairs. Their relationship was complex, with Constantijn offering both support and, at times, imposing his own expectations.

Christiaan maintained close relationships with his siblings, particularly his brother Constantijn Jr. They often corresponded about scientific matters and shared intellectual interests. Their familial bonds provided emotional support and intellectual stimulation throughout their lives.

Jean-Baptiste Colbert, the French Minister of Finance, was a key patron of Huygens during his time at the Académie Royale des Sciences. Colbert's support was instrumental in securing Huygens' position and providing him with resources for his research.

Due to his father's position, Huygens had connections with the Princes of Orange, which provided social standing. This afforded opportunities that would not have otherwise been available to him.