Crash: Mind over Mutant is a 2008 platform game developed by Radical Entertainment for the PlayStation 2, PlayStation Portable (ported by Virtuos), Wii and Xbox 360. It was released in North America on October 7, 2008, and was later released in Europe and Australia on October 30 and October 31, respectively. A separate version for the Nintendo DS was developed by Tose. It is the second game in the series not to have a Japanese release (after Crash of the Titans), the first to be published by Activision following its merging with the series' previous publisher Vivendi Games, and the last major console entry as a whole until 2017's Crash Bandicoot N. Sane Trilogy — a remaster of the first three Crash games.

Crash: Mind over Mutant is the fifteenth installment in the Crash Bandicoot video game series, and the seventh in the main franchise. The game's story centers on the arrival of a popular technological device (a parody of devices such as the iPhone and BlackBerry) that puts whoever uses it under the control of the device's creators, Doctor Neo Cortex and Doctor Nitrus Brio. Crash Bandicoot – protagonist of the series and only one unaffected by the device besides his spirit ally Aku Aku – must free his friends from the control of the device and put an end to Cortex and Brio's plot.

The title was met with generally mixed reviews, with opinions varying amongst its different versions. The PlayStation 2 and Wii versions saw generally favorable response, while the Xbox 360 version generated a less positive reaction. Much praise was aimed towards the voice acting and the satirical humor of the game's narrative, cutscenes and dialogue, while the unadjustable camera and extensive backtracking were criticised.

Mind over Mutant is a beat-'em-up game in which the player controls Crash Bandicoot, whose main objective is to explore his home, Wumpa Island, and surrounding environments to uncover the mystery behind the "NV", a personal digital assistant created by the main antagonist. Crash: Mind over Mutant is a mission-based game as opposed to Crash of the Titans's level-based structure, with goals being given by non-playable characters. Characters with exclamation points (!) over their heads, when talked to, give out important information that is needed to continue the story.

Scattered throughout the world are special items that empower Crash in one way or another. Golden stopwatches trigger a time-limited minigame which usually involves collecting objects or breaking things to earn bonuses. Red running shoes serve to temporarily power up Crash's kick attack and cause him to move faster, while the "Quad Damage" power-up can be used by Crash to temporarily multiply his attack power by four.

Crash can perform both a light and heavy-powered attack. He can also block, dodge-and-counter, or break an enemy's block. When he defeats enemies or destroys objects, a magical substance known as Mojo is released that, when collected, allows Crash's abilities to be upgraded.

While small minions require only a single combo attack for Crash to defeat, larger enemies, known as "Titans", require more effort to subdue. Each of the unique Titans in the game possess a star meter that indicates how close they are to being stunned. When the meter is full, the Titan is susceptible to "jacking", meaning Crash can mount the creature and control it. While controlled by the player, the Titan possesses a similar moveset to Crash, although some jacked Titans can shoot projectiles. Besides having more health, the Titans controlled by Crash have a purple Titan Meter which, when full, allows the Titan to unleash a powerful special attack. This fully drains the meter in the process.

A feature new to the series involves Crash storing a Titan in his pocket and utilizing it when it is most advantageous. When Crash is riding a Titan, any Mojo collected goes to the Titan. If enough is collected, the Titan's abilities are upgraded rather than Crash's.