Drew Blythe Barrymore (born February 22, 1975) is an American actress, talk show host, and businesswoman. A member of the Barrymore family of actors, she has received multiple awards and nominations, including a Golden Globe Award, an Emmy Award, and a BAFTA. She was named one of the 100 most influential people in the world by Time in 2023.

Barrymore rose to prominence as a child star in E.T. the Extra-Terrestrial (1982), and established herself as a Hollywood leading actress with roles in Firestarter (1984), Poison Ivy (1992), Boys on the Side (1995), Scream (1996), Ever After (1998), Never Been Kissed (1999), Charlie's Angels (2000), and Charlie's Angels: Full Throttle (2003). She has starred with Adam Sandler in The Wedding Singer (1998), 50 First Dates (2004), and Blended (2014). Her other notable film credits include Batman Forever (1995), Donnie Darko (2001), Confessions of a Dangerous Mind (2002), Music and Lyrics (2007), He's Just Not That Into You (2009), and Going the Distance (2010).

Barrymore won the Golden Globe Award for Best Actress in a Television Film for her portrayal of Edith Bouvier Beale in HBO's Grey Gardens (2009), played Sheila Hammond on the Netflix series Santa Clarita Diet (2017–2019), and hosts the daytime talk show The Drew Barrymore Show (2020–present).

Barrymore is the founder of the production company Flower Films and has starred in several of its projects. She made her directorial debut with Whip It (2009). She launched a range of cosmetics under the Flower banner in 2013. Her other business ventures include a range of wines, homeware, and clothing. She has released four New York Times bestselling books, including the memoir Little Girl Lost (1990) and the photobook Find It in Everything (2014).

Drew Blythe Barrymore was born on February 22, 1975, in Culver City, California, to actor John Drew Barrymore and aspiring actress Jaid Barrymore (born Ildikó Jaid Makó), who was born in a displaced persons camp in Brannenburg, West Germany, to Hungarian World War II refugees. Through her father, Barrymore has three older half-siblings, including actor John Blyth Barrymore. Her parents divorced in 1984.

In 2023, Barrymore displayed an AncestryDNA test onscreen on her talk show, which assessed her genetic ancestry as primarily European, with 6% Northern Indian.

Barrymore was born into an acting family. All of her paternal great-grandparents, Maurice and Georgie Drew Barrymore, Maurice and Mae Costello (née Altschuk), and her paternal grandparents, John Barrymore and Dolores Costello, were actors, with John being arguably the most acclaimed actor of his generation. Barrymore is a niece of Diana Barrymore, a grandniece of Lionel Barrymore, Ethel Barrymore and Helene Costello, and a great-great-granddaughter of Irish-born John and English-born Louisa Lane Drew, all of whom were also actors. She is a great-grandniece of Broadway idol John Drew Jr. and silent film actor, writer and director Sidney Drew.

Barrymore's godmothers are actress Sophia Loren and Lee Strasberg's widow, Anna Strasberg; Barrymore described her relationship with the latter as one that "would become so important to me as a kid because she was so kind and nurturing." Her godfather is filmmaker Steven Spielberg.