The Eastern Shore Stakes was an American Thoroughbred horse race run between 1913 and 1949 at Havre de Grace Racetrack, in Havre de Grace, Maryland. A race for two-year-old horses of either sex, it was inaugurated and run for most of its existence as the Eastern Shore Handicap.

The Eastern Shore Stakes has been run at various distances with thirty of its thirty-seven runnings at its longest distance of six furlongs.

On September 23, 1913, Tranid won the five and one-half furlong inaugural running of the Eastern Shore Handicap by two lengths for owner Schuyler L. Parsons. Tranid was trained by William H. Karrick and ridden by his son Kenneth.

Hourless, bred in France and foaled in England, was brought to race in the United States by his prominent owner and breeder, August Belmont Jr. In addition to winning the 1916 Eastern Shore Handicap, he won with three other important stakes for that age group. In 1917, Hourless won the Belmont Stakes and would be recognized as the U.S. Co-Champion Three-Year-Old Male Horse.

The 1917 edition of the Eastern Shore Handicap was won by Tippity Witchet, a gelding that would have a very successful career in racing which remarkably only ended twelve years later at age fourteen.

Future U.S. Racing Hall of Fame inductee Billy Kelly won the September 21, 1918 Eastern Shore Handicap for owner J. K. L. Ross who had purchased the horse on August 9 from trainer and co-owner William Perkins for $27,500.

Careful won the 1920 edition for owner Walter Salmon and would earn that year's American Co-Champion Two-Year-Old Filly honors. She came back to the Havre de Grace track the following year and defeated male competition again in winning the Chesapeake Stakes for three-year-olds. In 1922 Careful had another brilliant year that saw her named American Champion Older Female Horse.

Morvich kept his 1921 unbeaten streak going with his win in the Eastern Shore Handicap. He finished the year a perfect 11 for 11 and would go on to win the 1922 Kentucky Derby.