Egon and Peter share a complicated but ultimately loyal friendship. Peter often teases Egon's eccentricities, but he also respects his intelligence and depends on his expertise. Their contrasting personalities provide a comedic and dynamic element to the Ghostbusters team.

Egon and Ray share a deep bond based on their shared passion for science and the paranormal. Ray provides emotional support and often acts as a translator for Egon's complex ideas. They represent the heart of the Ghostbusters team.

Egon develops a romantic relationship with Janine Melnitz, the Ghostbusters' secretary. Their relationship is characterized by intellectual stimulation and mutual respect, although it is often strained by Egon's intense focus on his work. While unconventional, they have a strong and unique connection.