The first season of Desperate Housewives, an American television series created by Marc Cherry, commenced airing in the United States on October 3, 2004, concluded May 22, 2005, and consisted of 23 episodes. It tells the story of Mary Alice Young, a seemingly perfect housewife who commits suicide, fearing that a dark secret involving her, her husband, and their son would be exposed. At her wake, Mary Alice's four close friends and the main characters, Susan Mayer, Lynette Scavo, Bree Van de Kamp and Gabrielle Solis, are introduced. All of them live in the suburb of Fairview on Wisteria Lane. Narrating the series from beyond the grave, Mary Alice describes how her friends try to discover the reason for her suicide while dealing with the problems of their own personal lives.

Desperate Housewives' first season aired in the United States (U.S.) on Sundays at 9:00 pm ET on ABC, a terrestrial television network. In addition to the 23 regular episodes, a special, Sorting Out the Dirty Laundry, aired on April 24, 2005. The season garnered an average of 23.7 million viewers in the U.S. per all 23 episodes, ranking as the fourth most-watched television series during the 2004–05 American television season. In the United Kingdom, the season premiered on Channel 4 on January 5, 2005, and subsequently aired Wednesdays at 10 pm on the network. It aired in Canada on CTV Television Network and in Australia on the Seven Network.

The season was released on DVD as a six-disc box set under the title of Desperate Housewives – The Complete First Season on September 20, 2005, by Buena Vista Home Entertainment in Region 1, in Region 2 on October 10, 2005, and in Region 4 on November 28, 2005. The season is also available for purchase by registered users on the U.S. iTunes Store.

Marc Cherry wrote the script for the Housewives pilot and his agent shopped it to six networks (CBS, NBC, Fox, HBO, Showtime and Lifetime), only to have all of them turn it down. Later, after his previous agent was arrested for embezzlement, he hired a team of new agents, who saw the script "as a soap opera with dark comedy in it". After Cherry edited parts of the pilot script and pitched it to ABC, network executives were impressed, causing ABC to order 13 episodes. Filming for the season started around March 2004 at the Universal Studios Hollywood backlot Colonial Street.

This season was produced by Touchstone Television (now ABC Studios) and Cherry Productions and aired on the ABC network. The executive producers were Cherry, Michael Edelstein, Charles Pratt Jr., and Tom Spezialy with Pratt Jr., Chris Black, Oliver Goldstick, Joey Murphy, and John Pardee serving as consulting producers. The staff writers were Cherry, Goldstick, Spezialy, Pardee, Murphy, and Black; producers Alexandra Cunningham, Tracey Stern, and Patty Lin; co-executive producer Kevin Murphy, Jenna Bans, David Schulner, Adam Barr, Katie Ford, and Joshua Senter. Regular directors throughout the season included Charles McDougall, Arlene Sanford, Larry Shaw, Jeff Melman, Fred Gerber, David Grossman, and John David Coles. Its orchestral score was composed by Steve Bartek and Steve Jablonsky, while the series' theme was composed by Danny Elfman. Cherry also served as the season's show runner.

The first season features a cast of thirteen actors who receive star billing. Brenda Strong narrated the series as the deceased Mary Alice Young. Teri Hatcher portrayed Susan Mayer, the klutzy, lovable divorced mother in search of love. Felicity Huffman played Lynette Scavo, a former career woman who is now a full-time mother of four. Marcia Cross acted as Bree Van de Kamp, the uptight, perfectionist homemaker and mother of two teenagers who is struggling to save her marriage. Eva Longoria starred as Gabrielle Solis, the materialistic ex–fashion model who cheats on her husband. Nicollette Sheridan played the neighborhood slut and Susan's rival, Edie Britt. Steven Culp played Rex Van de Kamp, Bree's emasculated, sexually dissatisfied husband. Ricardo Antonio Chavira starred as Gabrielle's neglectful, high-powered executive husband, Carlos Solis. Mark Moses portrayed Mary Alice's mysterious widower, Paul Young. Andrea Bowen played Susan's knowledgeable, level-headed daughter, Julie Mayer. Jesse Metcalfe played the Solis' gardener and Gabrielle's adulterous lover, John Rowland. Cody Kasch played Mary Alice's and Paul's troubled and mentally unstable son Zach Young, and James Denton portrayed the neighborhood plumber and Susan's love interest, Mike Delfino, who has a secret of his own.

Numerous supporting characters have been given expansive and recurring appearances in the progressive storyline. Doug Savant played Tom Scavo, Lynette's husband who is often away on business; Savant later became a series regular. Shawn Pyfrom appeared as Bree and Rex's rebellious and headstrong son Andrew Van de Kamp. Kathryn Joosten acted as Karen McCluskey, Lynette's neighbor across the street, and Christine Estabrook portrayed the neighborhood busybody Martha Huber.

The pilot episode, which aired on October 3, 2004, garnered 21.6 million viewers, ranking first in its time slot of 9:00 pm Eastern Time Zone (ET) (8:00 pm Central Time Zone (Americas) [CT]). It was the most-viewed ABC season premiere since 1996's Spin City. After airing three episodes of Desperate Housewives, ABC picked the series up for a full season. Overall, the first season averaged 23.7 million viewers for the 23 episodes aired in the U.S., including the season's largest audience of more than 30 million viewers of the season finale. Of the regular primetime programming that aired during the 2004–2005 American television season, Desperate Housewives ranked 4th out of 156 programs, according to the Nielsen Ratings system. In terms of a Ratings share, Desperate Housewives ranked 3rd in the 2004-2005 TV Season, coming behind the two separate airing spots of American Idol. It also ranked as the highest ABC Network Programme. And the highest ranking Drama, Comedy and Dramady Programme.