Gypsy O'Brien (1889–1975) was a theater and film actress. Her theater performances included a role in Cheating Cheaters. She also appeared in Bunny at the Hudson Theatre. Her performance as the persecuted heroine was described as pretty and spirited. According to marketing materials she had titian hair. Her film debut was in The Soul Market in 1916. She portrayed an investigative reporter in Nothing But Lies.