Hannah Wilkinson married Samuel Slater, a highly influential figure in the early American textile industry, in 1798. This marriage marked a significant turning point in her life, bringing her into closer contact with the technological and economic innovations of the time.

During her marriage to Samuel Slater, Hannah gave birth to several children. Details about these children's names and specific birthdates are limited in readily available historical records. However, motherhood likely took a central role in her life during this period.

Hannah lived within the prominent household of Samuel Slater. This means that she directly benefitted from Slater's economic and social status, and likely had access to intellectual and cultural resources that were relatively uncommon at the time for other women. The Slater's house likely became a prominent location in the burgeoning New England industrial social scene.