A haruspex was a person trained to practise a form of divination called haruspicy in the religion of ancient Rome, the inspection of the entrails of sacrificed animals, especially the livers of sacrificed sheep and poultry. Various ancient cultures of the Near East, such as the Babylonians, also read omens specifically from the liver, a practice also known by the Greek term hepatoscopy (also hepatomancy).

The Roman concept is directly derived from Etruscan religion, as one of the three branches of the disciplina Etrusca.

The Latin terms haruspex and haruspicina are from an archaic word, hīra = "entrails, intestines" (cognate with hernia = "protruding viscera" and hira = "empty gut"; PIE *ǵʰer-) and from the root spec- = "to watch, observe". The Greek ἡπατοσκοπία hēpatoskōpia is from hēpar = "liver" and skop- = "to examine".

The spread of hepatoscopy is one of the clearest examples of cultural contact in the orientalizing period. It must have been a case of East-West understanding on a relatively high, technical level. The mobility of migrant charismatics is the natural prerequisite for this diffusion, the international role of sought-after specialists, who were, as far as their art was concerned, nevertheless bound to their father-teachers. We cannot expect to find many archaeologically identifiable traces of such people, other than some exceptional instances.

— Walter Burkert, 1992. The Orientalizing Revolution: Near Eastern Influence on Greek Culture in the Early Archaic Age (Thames and Hudson), p. 51.

The Babylonians were famous for hepatoscopy. This practice is mentioned in the Book of Ezekiel 21:21:

For the king of Babylon standeth at the parting of the way, at the head of the two ways, to use divination; he shaketh the arrows to and fro, he inquireth of the teraphim, he looketh in the liver.

One Babylonian clay model of a sheep's liver, dated between 1900 and 1600 BCE, is conserved in the British Museum.