Mirren had a relationship with actor Liam Neeson after meeting on the set of the film 'Excalibur' (1981). The relationship lasted several years and played a significant role in both their lives.

Mirren met director Taylor Hackford on the set of the film 'White Nights' (1985). They began a relationship that would lead to their marriage.

After dating for several years, Mirren married Taylor Hackford on December 31, 1997. They have remained married since then. Mirren does not have children and has spoken openly about her decision not to have them.