Helen Murray Free died on May 1, 2021, in Elkhart, Indiana, at the age of 98. Her death was due to complications from a stroke. Her legacy as a pioneering chemist and advocate for science education remains significant.

The work of Helen and Al Free in developing diagnostic test strips was designated a National Historic Chemical Landmark by the American Chemical Society on May 1, 2010, at the ETHOS Science Center in Elkhart, Indiana. This recognition underscored the profound impact of their innovations on medical diagnostics.