Gomel region, also known as Gomel oblast or Homyel voblasts, is one of the regions of Belarus. Its administrative center is Gomel. The total area of the region is 40,400 square kilometres (15,600 sq mi). As of 2024, it had a population of 1,338,617.

Its largest settlements include Gomel, Mazyr, Zhlobin, Svyetlahorsk, Rechytsa, Kalinkavichy, Rahachow and Dobrush.

Both Gomel region and Mogilev region suffered severely from the Chernobyl disaster. Gomel Province borders the Chernobyl Exclusion Zone in places, and parts of it have been designated as mandatory or voluntary resettlement areas as a result of the radioactive contamination.

Gomel region comprises 21 districts and 2 city municipalities. The districts have 278 selsovets, and 17 cities and towns.

Pripyatsky National Park covers 2% of the territory of the region. Eleven wildlife preserves of national importance cover 2.1% of the region.

The southernmost point of Belarus is located in Gomel region, on the Dnieper River to the south of the urban-type settlement of Kamaryn, Brahin District.

The 3rd largest lake in Belarus, Lake Chervonoye, is located in Gomel region, Zhytkavichy District.

Gomel region borders Mogilev region on the north, Brest region on the west, Russia (Bryansk oblast) on the east and Ukraine (Chernihiv oblast, Kyiv oblast and Zhytomyr oblast) on the south and southeast.