Howard County is a county in the state of Nebraska. As of the 2020 United States census, the population was 6,475. Its county seat is St. Paul. The county was formed in 1871 and named after Civil War General Oliver Otis Howard.

Howard County is part of the Grand Island metropolitan area.

In the Nebraska license plate system, Howard County is represented by the prefix 49 (it had the 49th-largest number of vehicles registered in the state when the license plate system was established in 1922).

The terrain of Howard consists of low rolling hills. The leveled hilltops are mostly used for agriculture. The Upper Loup River flows southeastward into the county near its NW corner, turning eastward to flow toward its junction with Middle Loup River. The Middle Loup River flows northeastward into the county near its SW corner, turning north to join with the Upper Loup River near the county midpoint to form the Loup River, flowing eastward into Merrick County. The county has a total area of 576 square miles (1,490 km²), of which 569 square miles (1,470 km²) is land and 6.3 square miles (16 km²) (1.1%) is water.

Prior to European settlement, the region that comprises Howard County was primarily home to the Pawnee people, with the Sioux occasionally traversing the area during hunting expeditions. A major Native American gathering place known as Indian Hill was located near present-day Cushing until the tribes were relocated in 1870.

The concept of organizing a settlement originated in early 1870 when James N. Paul, a government surveyor, explored the Loup River Valley on a hunting expedition with Major Frank North, the chief of the Pawnee scouts. Struck by the area's natural layout, James Paul later convinced his brother and fellow surveyor, Nicholas J. Paul, to establish a colony in the valley. On March 1, 1871, the Nebraska Legislature officially defined the boundaries of Howard County, carving it out from the northern section of Hall County. The county was named in honor of Civil War General Oliver Otis Howard, an abolitionist who served as the head of the Freedmen's Bureau.

In March 1871, the Paul brothers brought a group of 31 pioneers from Grand Island to stake homestead claims near what would become the county seat of St. Paul. To facilitate settlement into the interior, the pioneers constructed a cottonwood bridge across the Loup River by June 1871. The first county election took place on October 7, 1871, with only 54 residents casting ballots. Although the townsite committee initially pulled the name "Athens" out of a hat, the name was rejected due to an existing post office of the same name in the state. Senator Phineas Hitchcock subsequently suggested "St. Paul" to honor the founding Paul brothers. St. Paul officially secured its role as the permanent county seat during a contested election against the rival village of Dannebrog on October 13, 1874, winning by a vote of 226 to 208.

The late 19th century brought rapid, ethnically distinct immigration waves to Howard County, which grew to over 4,000 residents by 1880 and exceeded 10,000 by 1900. The southwestern portion of the county was heavily settled by Danish immigrants. In May 1871, Lars Hannibal led members of the Danish Land and Homestead Company from Wisconsin to establish a colony along Oak Creek. Named Dannebrog after the national flag of Denmark, the colony preserved a dense Danish heritage alongside the neighboring hamlets of Nysted and Dannevirke. In 1989, the Nebraska Legislature designated Dannebrog as Nebraska's Danish Capital.