Substituted arylalkylamines, also alternatively known in many cases as substituted arylethylamines, are a group of chemical compounds. These compounds are divided into two main categories: indolylalkylamines and phenylalkylamines.

These compounds are related to monoamine neurotransmitters, which are chemicals in the brain that transmit signals between nerve cells. Because of this, substituted arylalkylamines can have a wide range of effects on the body and mind. They are used in many medications, including:

Many arylalkylamines act as monoamine releasing agents, monoamine reuptake inhibitors, and/or monoamine receptor modulators.

Many more foundational arylalkylamines besides the above also exist. In addition, other alkylamines and non-aromatic cyclized alkylamines exist.