The Interborough Stakes, previously Interborough Handicap is an American Thoroughbred horse race held annually at the beginning of January at Aqueduct Racetrack in Ozone Park, Queens, New York. A non-graded stakes race open to fillies & mares age three and older, it is contested on dirt over a distance of six furlongs.

From its inaugural race in 1921 through 1955, the Interborough was open to both males and females. From 1956 on, it became a filly and mare event.

Inaugurated in 1921 at the Jamaica Race Course in Jamaica, Queens, it was raced there through 1958 after which it was hosted by the Aqueduct track. From 1968 through 1970, Belmont Park was home to the race.

From 1921 through 1924, the Interborough Handicap was contested at a distance of a mile and a sixteenth.

Ta Wee won this race in 1969 and 1970. Affectionately won it in 1963 and 1964.

In 2013, Nicole H became the first horse to win this race three times as well as consecutively.