Isobel Selina Miller Kuhn, born Isobel Selina Miller, aka, "Belle" (December 17, 1901 – March 20, 1957), known as Isobel Kuhn, was a Canadian Christian missionary to the Lisu people of Yunnan Province, China, and northern Thailand. She served with the China Inland Mission, along with her husband, John, as a Bible translator, church planter, Bible teacher, and evangelist. She authored nine books about her experiences.

Isobel Selina Miller was born in Toronto, Ontario, Canada, and moved with her family to Vancouver, British Columbia, when she was eleven years old. She was called "Belle" from the time she was a child. Her father was a roentgenologist and a Presbyterian lay preacher at a rescue mission, and her mother was president of the Women's Missionary Society in the Canadian Presbyterian church for many years. Her grandfather was an ordained Presbyterian minister.

Kuhn was raised in a loving Christian home although, in her words, it was without having "a direct confrontation with [the] living Savior" herself. After experiencing a "pitying sneer" from a skeptical University of British Columbia English professor, Kuhn decided that she did not need to know or seek the God her parents had been teaching her about. She became an agnostic, like many of her peers. A vivacious and popular young woman who did not drink or smoke, Kuhn was taught by her parents to do what was respectable and to "marry well," which meant she was to marry a man with a good education and social status like her own. While at the university, she had gained a lifetime membership in the coveted college drama troupe as a freshman, which was a rare honor.

Even though she had abandoned Christian teachings, she was still "considered a good girl, even a 'Christian'!," by some of her friends and acquaintances Yet after a crisis in which she discovered that the man to whom she was secretly engaged not only was unfaithful to her but also told her to expect the same treatment in their marriage, she was on the verge of taking her own life. Instead of drinking a bottle of poison from the bathroom medicine cabinet, however, Kuhn listened to the sound of her father's sleeping groans from his bedroom and remembered that he had been a "dear, kind father...." She went back to her bedroom and thought of a Latin quote from a Dante poem, which she believed was translated, "In His will is our peace." She considered that if God did exist, she certainly was not "in His will"; perhaps, she thought, that was why she had no peace.

Deciding to pray but not wanting to be duped by a "mental opiate," the unsure young woman whispered a prayer "with raised hands to God, to prove to her that He is and to give her peace; and, if He did she would give her whole life to Him - do anything He asked her to do, no matter what He asked - no matter where He asked her to go, for her whole life." Afterward, she decided to study the life of Jesus Christ in the Gospels. However, Kuhn was very much a secret Christian in the beginning, renouncing "worldly" pursuits a little at a time, but struggling to pray often.

In May, 1922, Isobel Kuhn graduated with honors in English Language and Literature, a major, from the University of British Columbia. Her intention was to become a dean of women and teach at a university. She taught third grade at the Cecil Rhodes School in Vancouver for more than a year, living in a boarding house because her family had moved to Victoria.

In 1924, while attending her second consecutive Christian summer missions conference at The Firs [original] in Bellingham, Washington, Kuhn met James O. Fraser, the conference speaker and the man who would become one of her greatest spiritual mentors and friends. The following September, Kuhn began studying at Moody Bible Institute in Chicago, Illinois. A staunch Canadian, the missionary-to-be never would have chosen this school on her own initiative; however, a Christian acquaintance who gave Kuhn the train fare and startup money for the first year requested that she go there. She had actually begun preparing to become a missionary by attending night classes at Vancouver Bible School.

At Moody, her energies were then focused on the Tibeto-Burman Lisu people, on the China-Burma [Myanmar] border, after meeting and hearing Mr. Frasier speak at The Firs and being convinced that was what God wanted her to do. Although she missed a semester of school because of illness, she graduated from Moody as valedictorian in December, 1926. At the school she had participated in open-air preaching, playing piano at a boy's reformatory, and working in neighborhood visitation ministries. For the most part, she also worked through school to pay her way, though she also received unexpected financial support when it was needed. At Moody she also met her future husband, John Becker Kuhn, whom she once called "another dreamer". He had started school a year earlier than his bride-to-be, and went to China alone, as was the mission's counsel at the time concerning unmarrieds when only one of them had been accepted by the mission.