Jack Yates Senior High School is a public high school near Texas Southern University in the historic Third Ward in Houston, Texas. Yates High School handles grades nine through twelve and is part of the Houston Independent School District (HISD). It is at 3650 Alabama Street.

Yates was named after Reverend John Henry "Jack" Yates, a former slave and a minister. Jack Yates and other leading blacks established the Houston Baptist Academy. Within a decade, the success of the school prompted Reverend Yates to reorganize the Houston Baptist Academy as the Houston College, the school offered a special opportunity to the black children of the community who sought an alternative to the Colored High School of the public school system.

Yates has HISD's magnet program for communications: broadcast TV, radio, print, and photography. Yates also houses a maritime studies magnet program.

In 2010, Paul Knight of the Houston Press wrote that "the school remains a symbol of solidarity in the Third Ward."

In June 2016, members of the Jack Yates and HISD communities held a ground-breaking ceremony for the new campus. A $59.4 million campus was completed next to the old campus in summer 2018.

Yates was established on February 8, 1926, as Yates Colored High School with 17 teachers and 600 students. The school, at 2610 Elgin, was the second school for African-Americans in Houston. At the time schools were segregated on the basis of race.

Previously Houston had only one secondary school for black people, Colored High School. In 1925 the school board stated that it would build a new black high school due to the increasing black population. The Houston Informer stated that the schools need to be named after prominent black people from the city and/or other successful black persons. The new high school was to be named after Jack Yates, a prominent black Houstonian, and the original colored high school was renamed Booker T. Washington High School.

The original Yates High was built from a $4 million (about $73434535.1 when accounting for inflation) bond program, which included $500,000 (about $9179316.89 when accounting for inflation) to renovate 17 existing schools and build new schools. Clifton Richardson, the editor of the Houston Informer, had felt skepticism towards this proposal but ultimately asked Houston's African-Americans to vote for the bond and endorsed it in the Informer. In 1925, HISD originally proposed to have the school built for $100,000 (about $18358633.78 when accounting for inflation), but Richardson opposed this plan, prompting the district to revise the bond. The first principal, James D. Ryan, served from the opening until his death in 1941; William S. Holland became Yates's second principal that year.