Jean Eyeghé Ndong (born 12 February 1946) is a Gabonese politician. He was the Prime Minister of Gabon from January 20, 2006 to July 17, 2009. He was also the First Vice-president of the Gabonese Democratic Party (PDG) until 2009.

Eyeghé Ndong resigned as prime minister in July 2009 and announced his intention to stand as an independent candidate in the August 2009 presidential election. Subsequently, he withdrew his candidacy in favor of a joint opposition candidate, André Mba Obame, and acted as spokesman for the opposition. He has been vice-president of the National Union, a unified opposition party, since its creation in February 2010.

Eyeghé Ndong, who was born in Libreville, is a nephew of Léon M'ba, who was President of Gabon from 1960 to 1967. He was administrative director of the National Social Security Fund (CNSS) from 1984 to 1990, then Deputy Director-General of the CNSS from 1990 to 1991 and Deputy Director-General of the National Social Guarantee Fund from 1991 to 1996.

In the December 1996 parliamentary election, Eyeghé Ndong won a seat in the National Assembly of Gabon as a PDG candidate in the second arrondissement of Libreville. He was then appointed to the government as Secretary of State under the Minister of Finance on 28 January 1997 and therefore did not sit in the National Assembly until 1999, when he was excluded from the first government of Prime Minister Jean-François Ntoutoume Emane.

Eyeghé Ndong again ran as the PDG candidate for the first seat from the second arrondissement of Libreville in the December 2001 parliamentary election, but on that occasion he was defeated by Paul Mba Abessole of the National Rally of Woodcutters - Rally for Gabon (RNB-RPG). In the first round he placed second with 32.54% of the vote, behind Mba Abessole's 38.52%. Despite his failure to win a seat, he was appointed to Ntoutoume Emane's government as Minister-Delegate under the Minister of State for the Economy, Finance, the Budget, and Privatization on January 27, 2002; he worked in that capacity alongside another minister-delegate, Senturel Ngoma Madoungou. In the December 29, 2002 local elections, he was elected as a municipal councillor in Libreville, and he was subsequently elected to the Senate.

Eyeghé Ndong remained in his position as minister-delegate at the Ministry of Finance for four years. He was then appointed to succeed Ntoutoume Emane as prime minister on January 20, 2006, one day after President Omar Bongo was sworn in for another term. He was also named vice-president of the PDG in October 2006.

Competing for the first seat in the 2nd and 6th Arrondissements of Libreville, Eyeghé Ndong and Mba Abessole faced each other again in the December 2006 parliamentary election. Thus Eyeghé Ndong, the prime minister, challenged Mba Abessole, who was deputy prime minister. Eyeghé Ndong was victorious, winning 66.52% of the vote. Eyeghé Ndong submitted the resignation of his government to Bongo on January 19, 2007, observing a constitutional requirement that the government resign after the results of a parliamentary election were announced by the Constitutional Court. On January 24, Bongo asked Eyeghé Ndong to form a new government, and Eyeghé Ndong accepted; the composition of the new government was announced on January 25, with few changes. A new government under Eyeghé Ndong was named on December 28, 2007, with its size reduced from 50 to 41 ministers.

In the April 2008 local elections, Eyeghé Ndong prevailed in the second arrondissement of Libreville, again defeating Mba Abessole. A new 44-member government headed by Eyeghé Ndong was appointed on October 7, 2008.