Scott made her debut for the England senior team against the Netherlands in August 2006.

Scott scored her first international goal in the 6–1 win over Argentina in the 2007 FIFA World Cup.

Scott scored a late winner as England beat the Netherlands in the semi-final of the 2009 UEFA Women's European Championships.

Scott scored against New Zealand in England's 2–1 group B win at the 2011 FIFA Women's World Cup.

Scott represented Great Britain at the 2012 Olympic Games, scoring against Cameroon.

Scott made her 150th appearance for England in a 6–0 win over Northern Ireland.

Scott was part of the England squad that won the UEFA Women's Euro 2022, making four substitute appearances including the final against Germany.