Jon Jones was born in Rochester, New York, to Arthur and Camille Jones. He was raised alongside his siblings, including former NFL player Arthur Jones and professional football player Chandler Jones.

While a senior in high school, Jones became the 2005 New York State wrestling champion, showcasing his early athletic prowess.

Jones made his professional MMA debut in April 2008. He amassed an undefeated record of 6–0 over a period of three months, finishing all of his opponents.

Jones made his UFC debut against André Gusmão at UFC 87, winning via unanimous decision (30–27, 29–28, and 30–27).

Jones defeated Maurício Rua at UFC 128 to become the youngest UFC champion at age 23, winning the light heavyweight title.

Jones was involved in several controversies, including a hit-and-run incident and positive tests for banned substances, leading to multiple suspensions and title losses.

Jones defeated Alexander Gustafsson at UFC 232 to win the vacant light heavyweight title, marking his second championship reign.

Jones vacated the light heavyweight title and announced his move to the heavyweight division, seeking higher pay and new challenges.

Jones defeated Ciryl Gane at UFC 285 to win the vacant heavyweight title, becoming a two-division champion.

Jones defended his heavyweight title against Stipe Miocic at UFC 309, winning by technical knockout and breaking the record for most title defenses in UFC history.